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1982 (2)
1Author    Bernd Sorg, Erich HeckerRequires cookie*
 Title    On the Chemistry of Ingenol, III [1] Synthesis of 3-Deoxy-3-oxoingenol, Some 5-Esters and of Ethers and Acetals of Ingenol  
 Abstract    3-Deoxy-3-oxoingenol (3) was prepared from ingenol-5,20-acetonide (25) by oxidation and subsequent removal of the acetonide. 3 was acylated to give homologous 5,20-di-acylates 5-9. From these the 5-monoacylates 14, 15 and 17 were obtained in only moderate yields. Therefore the 20-silyl ether 10 (prepared from 3) was acylated. After smooth removal of the silyl ether the homologous 5-acylates 16. 18 and 19 resulted in good yield. The 5,20-dibutyrate 6 and all 5-acylates prepared (14-19) showed no irritant activity on the mouse ear. The 3-oxo-5-acylates 14-19 could not be reduced to give ingenol-5-acylates (24). Therefore various ingenol derivatives, 29-32, with suitable protected hydroxyl func-tions as well as the corresponding 5-clecanoates 35-38 were synthesized. The protecting groups of the derivatives 35-38 could however not be cleaved off to yield ingenol-5-decanoate (24). 
  Reference    Z. Naturforsch. 37b, 1640—1647 (1982); eingegangen am 2. Juli 1982 
  Published    1982 
  Keywords    Cocarcinogen, Diterpenes, Ingenol Esters, Tumor Promoter 
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 TEI-XML for    default:Reihe_B/37/ZNB-1982-37b-1640.pdf 
 Identifier    ZNB-1982-37b-1640 
 Volume    37 
2Author    JosephI. Okogun, AkinboA. Adesomoju, G. Eorge, A. A. Desida, HansJörg Lindner, G.Erhard HabermehlRequires cookie*
 Title    Roseanolone: A New Diterpene from Hypoestes rosea  
 Abstract    Roseanolone is a new diterpene from the African plant Hypoestes rosea (Acanthaceae). The iso­ lation is described; the structure has been determ ined to be l,2,3,3a,4,5,6,6a,7,8,9,10a-do-decahydro-5-hydroxy-3-isopropyl-3a, 6-oxa-6,9,10a-trim ethyl-dicyclopenta[a,d] cycloocten-l-one by X-ray crystallography. 
  Reference    Z. Naturforsch. 37c, 558—561 (1982); received February 12 1982 
  Published    1982 
  Keywords    Roseanolone, Diterpenes, Acanthaceae, X -R ay Structure Analysis 
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 TEI-XML for    default:Reihe_C/37/ZNC-1982-37c-0558.pdf 
 Identifier    ZNC-1982-37c-0558 
 Volume    37