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1981 (1)
1Author    H. J. Opferkuch, W. Adolf, B. Sorg, S. Kusumoto+, E. HeckerRequires cookie*
 Title    Zur Chemie des Ingenols, I Ingenol und einige seiner Derivate On the Chemistry of Ingenol, I Ingenol and Some of its Derivatives  
 Abstract    The tetracyclic polyfunctional diterpene ingenol (1) is the prototype of many di-terpenoid parent alcohols of the ingenane type. Esters of these parent alcohols occur -partly together with esters of polyfunctional diterpene parent alcohols of the tigliane and daphnane type -as irritant, cocarcinogenic and antineoplastic principles in species of the family Euphorbiaceae (Spurge). Preparation of 1 from latex of Euphorbia ingens E.May as well as of some functional derivatives of 1 are described. 
  Reference    Z. Naturforsch. 36b, 878—887 (1981); eingegangen am 2. März 1981 
  Published    1981 
  Keywords    Cocarcinogens, Diterpene Esters, Euphorbiaceae, Tumor Promoters 
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 TEI-XML for    default:Reihe_B/36/ZNB-1981-36b-0878.pdf 
 Identifier    ZNB-1981-36b-0878 
 Volume    36 
2Author    Bernd Sorg, Erich HeckerRequires cookie*
 Title    Zur Chemie des Ingenols, II [1] Ester des Ingenols und des A 18 -Isoingenols On the Chemistry of Ingenol, II [1] Esters of Ingenol and Zl 7 -8 -Isoingenol  
  Reference    Z. Naturforsch. 37b, 748—756 (1982); eingegangen am 3. Februar 1982 
  Published    1982 
  Keywords    Cocarcinogens, Ingenol, Initiation-Promoter, Irritants, Diterpene Esters 
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 TEI-XML for    default:Reihe_B/37/ZNB-1982-37b-0748.pdf 
 Identifier    ZNB-1982-37b-0748 
 Volume    37 
3Author    T. Schäfer3, B. Sorg, C. Karalaib, E. HeckerRequires cookie*
 Title    On the Chemistry of Resiniferonol, II [1] Preparation and Bioactivities of 15,16-Dihydrosimplexin and Methods for its Tritium Labeling  
 Abstract    Excoecaria factor 0 1 -the daphnane type polyfunctional diterpene ester 5 /S-hydroxy-6 a,7 a-epoxyresiniferonol-9,13,14-orf/i0-(2,4,6-decatrienoate) -may be obtained in reason­ able amounts from the latex of Excoecaria oppositifolia from South East Asia. 0 1 was par­ tially hydrogenated with H2-Pd/C to yield, by saturation of the three double bonds in the orthoester, and of J 1516 in the diterpene moiety, the new 15,16-dihydro derivative of simple­ xin. The latter is the well known daphnane prototype of polyfunctional diterpene esters occurring in Euphorbiaceae and Thymelaeaceae. 15,16-Dihydrosimplexin (DHS) showed pro­ nounced irritant and tumor promoting activities. By analogous hydrogenation of 0 1 with a mixture of 1H2/3H2 a selectively labeled [3H]DHS was obtained that exhibited a particularly high specific activity of 30 Ci/mmole. Thus it is considered most appropriate for use to study the toxicokinetics and -dynamics of daphnane type diterpene esters. To device an alternative of 3H-labeling of DHS or simplexin (SIM) in position 20 of the diterpene moiety DHS-5-ben-zoate was oxidized by pyridinium chlorochromate. The resultant 20-aldehyde was reduced by sodium borohydride to reconstitute DHS-5-benzoate and, after deprotection, DHS. This route appears appropriate to prepare similarly [20-3H]DHS as well as [20-3H]SIM using sodium [3H]borohydride. 
  Reference    (Z. Naturforsch. 49b, 128—134 [1994]; received September 61993) 
  Published    1994 
  Keywords    Daphnane Derivatives, Diterpene Esters, Simplexin, Skin Irritant Activity, Skin Tumor Promoting Activity 
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 TEI-XML for    default:Reihe_B/49/ZNB-1994-49b-0128.pdf 
 Identifier    ZNB-1994-49b-0128 
 Volume    49