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1996 (1)
1Author    IouriE. Borissevitcha+, ChristianeP F Borgesa++, GalinaP. Borissevitcha+++, VictorE. Yushmanova+, SoniaR W Louroh, Marcel TabakaRequires cookie*
 Title    Binding and Location of Dipyridamole Derivatives in Micelles: the Role of Drug Molecular Structure and Charge  
 Abstract    Binding and localization of the vasodilator and antitumor drug coactivator dipyridamole (D IP) and of its three derivatives, RA14. RA47 and RA25 (D IP D), to cationic (cetyltrimeth-ylammonium chloride), anionic (sodium dodecylsulfate), zwitterionic (N-hexadecyl-N.N-di-methyl-3-ammonio-l-propanesulfonate). and neutral (r-octylphenoxypolyethoxyethanol) m i­ celles was studied using fluorescence, optical absorption and 'H N M R spectroscopy. The analysis of N M R . optical absorption and fluorescence data indicates that the depth of local­ ization of the drugs in the micelles from the surface decreased in the order D IP > RA 14 > RA47 > RA25. The binding constants for the neutral drug forms change in the same order in the range of 1400-3100 m _1 for D IP to 80-300 m _1 for RA25. This order is identical with the reported biological activity of D IP D . For the protonated drugs in zwitterionic or neutral micelles the binding constants are reduced by a factor of 20-75. 
  Reference    Z. Naturforsch. 51c, 578—590 (1996); received March 28/May 31 1996 
  Published    1996 
  Keywords    Dipyridamole and Derivatives, Micelle, Drug Location, Absorption, Fluorescence, N M R 
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 TEI-XML for    default:Reihe_C/51/ZNC-1996-51c-0578.pdf 
 Identifier    ZNC-1996-51c-0578 
 Volume    51