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1983 (1)
1Author    Umlagerung Synthese, Eigenschaften Diphenylphosphinosubstituierter Uracile, Jochen Ellermann, AlfonsA M DemuthRequires cookie*
 Title    Chemie polyfunktioneller Moleküle, 74 [1] [1] Synthesis, Rearrangement and Properties of Diphenylphosphino Substituted Uracils  
 Abstract    5-Bromo-uracil (2) with chloro-diphenylphosphine and triethylamine gives 5-bromo-N(1),N(3)-bis(diphenylphosphino)-uracil (3). In moist acetone, 3 is hydrolyzed to 5-bromo-N(l)-diphenylphosphino-uracil (4). 3 reacts with n-butyllithium under rearrangement and, with HCl, under elimination of a PPh2-group, forms C(5)-diphenylphosphino-uracil (7 a). Recrystallization of 7 a from ethanol yields the ethanol-1:1-adduct 7 b. Heating of 7 a in dimethylsulfoxide with D20 yields the N(l),N(3)-dideutero-C(5)-diphenylphosphino-uracil (7 c). All compounds were characterized by infrared, Raman, iH, 31 P NMR and mass spectra. 7 a shows a very small antitumor activity. 
  Reference    Z. Naturforsch. 38b, 1165—1172 (1983); eingegangen am 19. Mai 1983 
  Published    1983 
  Keywords    Diphenylphosphino Substituted Uracils, Rearrangement, NMR Spectra, Vibrational Spectra, Mass Spectra 
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 TEI-XML for    default:Reihe_B/38/ZNB-1983-38b-1165.pdf 
 Identifier    ZNB-1983-38b-1165 
 Volume    38