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1998 (1)
1Author    H. Nohl, L. GilleRequires cookie*
 Title    Evaluation of the Antioxidant Capacity of Ubiquinol and Dihydrolipoic Acid  
 Abstract    Ubiquinone and a-lipoic acid are natural constitutents which are involved in mitochondrial energy metabolism. Their bioenergetic activities require redox-cycling. In the case o f a-lipoic acid redox-cycling leads to dihydrolipoic acid which occurs in multienzyme com plexes in­ volved in the citric acid cycle while U Q recycles through semi-and divalently reduced ubiqui­ nones in the respiratory chain. We have proved the validity of the concept about the antioxi­ dant function o f these natural compounds in their reduced form. Ubiquinol was found to interfere with lipid peroxidation o f liposomal membranes being itself degradated by two consecutive oxidation steps. Dihydrolipoic acid was found to totally recycle ubiquinone to the antioxidant active divalently reduced form. In contrast to the antioxidative derived reaction products of ubiquinols which in turn promoted lipid peroxidation, the antioxidant derived reaction product o f dihydrolipoic acid was the unreactive two electron oxidation product a-lipoic acid. Our experim ents demonstrate the existence of an dihydrolipoic acid driven recycl­ ing of U Q to the antioxidative-a c tiv e U Q H 2. The efficiency o f the antioxidative capacity of the latter was found to be diminished through prooxidant activities of the antioxidant-derived metabolites. 
  Reference    Z. Naturforsch. 53c, 250 (1998); received D ecem ber 19 1997/February 3 1998 
  Published    1998 
  Keywords    Ubiquinol, Coenzyme Q, Dihydrolipoic Acid, Lipid Peroxidation, Oxygen Radicals 
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 TEI-XML for    default:Reihe_C/53/ZNC-1998-53c-0250.pdf 
 Identifier    ZNC-1998-53c-0250 
 Volume    53