| 1 | Author | Prof Dr, Ernst | Requires cookie* |
| Title | Zur Festphasenpeptidsynthese des Makrophagen-migrationsinhibierenden Faktors der Maus (mMIF): Ein Vergleich verschiedener Syntheseansätze zur Darstellung der schwierigen C-terminalen Sequenz mMIF(93-115)  | ||
| Abstract | Solid Phase Peptide Synthetic A ppro ach es to M ouse M acrophage M igration Inhibitory Factor (m M IF): C om parison of D ifferent Strategies Producing the C-Terminal D ifficult Sequence P eptide m M IF (9 3 -1 1 5) Thom as Kaiser, W olfgang V oelter* From solid phase peptide synthetic approaches of mMIF(93-115) the C-terminal sequence turned out to be a typical "difficult sequence" peptide. Various stepwise syntheses were performed with different resins and coupling reagents. The Peptide was synthesized in 90% yield by solid phase fragment condensation of protected mMIF(93-108) to mMIF(109-115) '2-Chlorotrityl' resin bound. | ||
| Reference | Z. Naturforsch. 52b, 281—295 (1997); eingegangen am 4. Dezember 1996 MIF | ||
| Published | 1997 | ||
| Keywords | Solid Phase Peptide Synthesis, Difficult Sequence, Fragment Condensation, Coupling Conditions | ||
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