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'Deoxyribonucleotide Synthesis' in keywords
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1985 (1)
1984 (1)
1Author    Helga BaumRequires cookie*
 Title    Aurintricarboxylic Acid and Polynucleotides as Novel Inhibitors of Ribonucleotide Reductases  
 Abstract    , R üdiger H ofm ann, M anfred L am m ers, G a b rie le S ch im p ff-W eilan d , and H artm ut F ollm ann Fachbereich Chem ie (Biochem ie) der Philipps-U niversität Marburg, H ans-M eerwein-Straße, Ribonucleoside diphosphate reductases isolated from Escherichia coli, baker's yeast, Ehrlich ascites tumor cells, and a unicellular green alga (Scenedesmus obliquus) are inhibited strongly and uniformly by the polymeric triphenylmethane dye, aurintricarboxylic acid. The m olecule appears to interact simultaneously with the enzyme's various nucleotide and catalytic (iron-organic radical) sites. Oligo-and polyribonucleotides are also inhibitory. T hese reactions serve as m odels o f the probably physiologic regulation o f ribonucleotide reduction exerted by natural inhibitors. Partial characterization o f an inhibitor fraction found in wheat seed em bryo is described. 
  Reference    Z. Naturforsch. 39c, 276—281 (1984); received October 19 1983 
  Published    1984 
  Keywords    Deoxyribonucleotide Synthesis, Enzyme Regulation, Protein-N ucleic Acid Interaction, Wheat Oligonucleotides 
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 TEI-XML for    default:Reihe_C/39/ZNC-1984-39c-0276.pdf 
 Identifier    ZNC-1984-39c-0276 
 Volume    39 
2Author    Rüdiger Hofm, H. Artm, Ut FollmannRequires cookie*
 Title    Bleom ycin-Iron C om plex and Oxygen Activate Algal R ibonucleotide Reductase  
 Abstract    Ribonucleotide reductase of green algae (Scenedesmus obliquus) is a radical-containing enzyme which rapidly loses activity under anaerobic conditions. Reactivation in the presence of air is enhanced by 10 |j.m iron(II)-bleomycin chelate. The reaction lends new biochemical potential to the antibiotic and should be valuable in mechanistic studies of ribonucleotide reduction. 
  Reference    Z. Naturforsch. 40c, 919—921 (1985); received August 22 1985 
  Published    1985 
  Keywords    Bleomycin, Deoxyribonucleotide Synthesis, Iron, Oxygen Dependence, Ribonucleotide Reduction, Scenedesmus obliquus 
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 TEI-XML for    default:Reihe_C/40/ZNC-1985-40c-0919_n.pdf 
 Identifier    ZNC-1985-40c-0919_n 
 Volume    40