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1988 (1)
1983 (1)
1Author    N. Gulfo, R. Bartucci, L. SportelliRequires cookie*
 Title    Effect of Inhalation Anesthetics on Spin-Labeled Cholesterol Containing DPPC Vesicles  
 Abstract    We have investigated by means of electron spin resonance (ESR) spectroscopy the influence of three inhalation anesthetics, i.e. halothane, chloroform and diethyl ether, on the interfacial and hydrophobic region as well of 38 mol% cholesterol containing DPPC unilamellar vesicles. The study has been carried out in the temperature range 25-45 °C. The variation of the order parameter, S, vs temperature of the lipid phase indicates that with this content of cholesterol the characteristic gel liquid crystalline main phase transition of DPPC, normally occurring at T x ~ 41 °C, disappears. When halothane and chloroform are added to the vesicles suspension up to [DPPC]/[anesthetic] molar ratio of 1:1 the main phase transition, as detected with the stearic acid spin label 7(12,3), reappears again and it results down shifted at 7, ~ 35 and 39 °C, respectively. In presence of diethyl ether, instead, the main phase transition is not observable also at the highest concentration of anesthetic used. Moreover, halothane and chloroform affect similarly the hydrophobic core of choles-terol-!-DPPC vesicles which, in turn, results to be different from the action exerted by diethyl ether in the same region. The ESR findings are discussed in terms of competitive effects shown by cholesterol and inhalation anesthetics. Moreover, the interfacial region of CHOL + DPPC vesicles results to be the target of anesthetics. 
  Reference    Z. Naturforsch. 43c, 264—268 (1988); received August 12/November 24 1987 
  Published    1988 
  Keywords    Cholesterol, DPPC, Inhalation Anesthetics, ESR 
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 TEI-XML for    default:Reihe_C/43/ZNC-1988-43c-0264.pdf 
 Identifier    ZNC-1988-43c-0264 
 Volume    43 
2Author    Srabani Banerjee, S. N. ChatterjeeRequires cookie*
 Title    Effect of Sodium Cholate on the Phase Transition Temperature of Dipalmitoyl Phosphatidylcholine  
 Abstract    On treatm ent with sodium cholate, the phase transition tem perature (Tc) of m ultilam ellar liposomes derived from dipalm itoyl phosphatidylcholine (DPPC) progressively decreased with increasing cholate: lipid-P m olar ratio. A molar ratio of 4.5 caused a one degree depression in Tc. The unilamellar cholate vesicles o f DPPC exhibited the same Tc as that o f the m ultilam ellar ones. The formation of unilam ellar vesicles from the m ultilam ellar ones by cholate treatm ent was in­ vestigated by electron microscopy. 
  Reference    Z. Naturforsch. 38c, 302—306 (1983); received Septem ber 20/N ovem ber 15 1982 
  Published    1983 
  Keywords    Liposomes, DPPC, Sodium Cholate, Phase Transition, Electron Microscopy 
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 TEI-XML for    default:Reihe_C/38/ZNC-1983-38c-0302.pdf 
 Identifier    ZNC-1983-38c-0302 
 Volume    38