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1999 (1)
1975 (1)
1Author    Pavel Balgavý, Robert TurekRequires cookie*
 Title    Inhibition of Excision Repair without Influence upon UV-Sensitivity and UV-Mutability in Escherichia coli B/r Hcr +  
 Abstract    Pre-irradiation starvation of exponentially growing Escherichia coli B/r Hcr+ thy~trp~ strain for thymine and tryptophan causes inhibition of pyrimidine dimer excision from ultraviolet damaged cells DNA. This inhibition of excision repair has not resulted in increasing ultraviolet sensitivity nor in increasing frequency of ultraviolet induced tryptophan revertants. The possible mechanisms of the non-excision repair in the prestarved cells, which is at least as accurate and effective as the whole dark repair in exponentially growing cells, are discussed. 
  Reference    (Z. Naturforsch. 30c, 406 [1975]; received August 1/November 22 1974) 
  Published    1975 
  Keywords    DNA-Repair, UV-Sensitivity, UV-Mutagenesis, Escherichia coli, UV-Radiation 
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 TEI-XML for    default:Reihe_C/30/ZNC-1975-30c-0406.pdf 
 Identifier    ZNC-1975-30c-0406 
 Volume    30 
2Author    Karlheinz Tempel, Hannelore Kortenbeutel, Christina Von ZallingerRequires cookie*
 Title    Bleomycin -Induced DNA Damage and DNA Repair in Chicken Embryo Cells as Compared to X-Irradiation  
 Abstract    Following in vitro-and in ovo-exposure of chicken embryo cells, the level of bleomycin (BM) -induced damage was evaluated by using DNA synthesis, nucleoid sedimentation (SED), and viscometry of alkaline cell lysates (VISC). This damage was compared to X-irradiation, using 5.9-378 nM BM in vitro, 1.5-116 (.ig BM/egg in ovo, and 2-32 Gy, respec­ tively, in vitro as well as in ovo. With respect to BM. the most notable result is the increase in D N A synthesis and VISC at the lowest concentrations of the drug. A decrease in both parameters was observed at high BM concentrations and following exposure to X-rays, con­ comitantly with an increase in SED. Regarding the radiomimetic drug BM and X-rays, dif­ ferent modes of DNA damage and D N A repair are suggested by previous investigations and the present results. Therefore, further evidence is presented, that the chicken embryo can act as a simple, rapid and inexpensive test system to characterize the biological effects of many nucleo-and/or cytotoxic agents. 
  Reference    Z. Naturforsch. 54c, 1068—1074 (1999); received July 14/September 3 1999 
  Published    1999 
  Keywords    Bleomycin, Chicken Embryo, DNA-Damage, DNA-Repair, Nucleoids, X-Irradiation 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-1068.pdf 
 Identifier    ZNC-1999-54c-1068 
 Volume    54