| | 1 | Author
| Gianfranco Menestrina, Flavia Pasquali | Requires cookie* | | | Title
| Effects of Carbohydrates on the Ion Conductance of the Hemocyanin Channel  | | | | Abstract
| The effects o f glucose and sucrose on the ionic conductance properties o f the channel formed by Megathura crenulata hemocyanin in planar lipid bilayers have been studied using m em branes o f different compositions. It was found that glucose at high concentrations strongly affects the time constants o f the current relaxations observed in m em branes containing many channels after a step in the voltage clamp from ground to a positive value. At m uch lower concentrations both sucrose and glucose strengthened the binding o f Ba2+ to the protein, what in turn has the effect to shift the conductance voltage curve o f the pore towards negative potentials. The possible mechanism underlying these effects and the analogies with other studies on the interaction o f sugars and alcohols with proteins have been discussed. | | | |
Reference
| Z. Naturforsch. 40c, 85—9 (1985); received October 25 1984 | | | |
Published
| 1985 | | | |
Keywords
| Hemocyanin Channel, Planar Lipid Bilayer, Carbohydrates, D ivalen t Cations, Protein Conformations | | | |
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| default:Reihe_C/40/ZNC-1985-40c-0085.pdf | | | | Identifier
| ZNC-1985-40c-0085 | | | | Volume
| 40 | |
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