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1Author    Yoshimitsu Yamazaki, MidoriG. Oto1, ^. Yu-Ichi, Takenori Kageyama, Hiroaki Tomohiro, OkunoRequires cookie*
 Title    Structure of Chloro(cyclopentadienone)- (cyclopentadienyl)ruthenium and its Cytotoxic Activity  
 Abstract    The structure of R u(cpO)(cp)C l com plex (3), which was precipitated from aqueous solutions of R u(cp)2Cl+PF6' (1), was determined by X-ray crystallographic analysis. The Ru-halogen bond distance was shorter and the dihedral angle be­ tween the rings was larger than the values re­ ported for the corresponding Br analogue, R u(cpO)(cp)Br (4). The com plex 3 (IC50 1 09 /iM) was more cytotoxic than 1 (IC50 163 //M) against mouse sarcoma S I80 cells, but less toxic than 4 (IC50 72 ,/M). 
  Reference    Z. Naturforsch. 51b, 301 (1996); received September 21 1995 
  Published    1996 
  Keywords    Ruthenium Complex, Cytotoxicity, X-Ray, Cyclic Voltammetry 
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 TEI-XML for    default:Reihe_B/51/ZNB-1996-51b-0301_n.pdf 
 Identifier    ZNB-1996-51b-0301_n 
 Volume    51 
2Author    Ping-Lu LiRequires cookie*
 Title    Cytotoxicity of Cobra (Naja naja kaouthia) Venom on Rabbit Red Blood Cells and S-180 Tumor Cells in the Presence of Tetracaine, Lidocaine and Procaine  
 Abstract    The cytocidal action of Naja naja kaouthia venom on rabbit red blood cells and S-180 tumor cells treated with local anesthetics (tetracaine, lidocaine and procaine) were studied. The S-180 cells were more sensitive to the venom than the red blood cells which required albumin for ef­ ficient hemolysis in the 10 minute assay. All three local anesthetics at lower concentrations protected both cell types against venom hemolysis. At higher concentrations the local anesthetics enhanced the cell lysis to 100%. The effectiveness of the local anesthetics for both the inhibition and enhancement phases of cytotoxicity was tetracaine > lidocaine > procaine. This is the same order as their anesthetic effectiveness, lipid solubility and their protein binding. 
  Reference    Z. Naturforsch. 35c, 268 (1980); received October 8 1979 
  Published    1980 
  Keywords    Local Anesthetics, Cobra Venom, Cytotoxicity, Erythrocytes, Tumor Cells 
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 TEI-XML for    default:Reihe_C/35/ZNC-1980-35c-0268.pdf 
 Identifier    ZNC-1980-35c-0268 
 Volume    35 
3Author    DanielN. Kushev, NadejdaC. Spassovska, SvetoslavI. Taxirov, KonstantinC. GrancharovRequires cookie*
 Title    Cytotoxicity and Antitumor Activity of Platinum(II) Complexes of Aromatic and Cycloalkanecarboxylic Acid Hydrazides  
 Abstract    N ew platinum(II) complexes of cyclohexanecarboxylic acid hydrazide (chcah) were synthe­ sized and characterized by elem ental analysis, IR. and 'H NM R spectra. Their inhibitory effects on cell growth and macromolecular synthesis o f Friend leukem ia cells in culture as well as the in vivo antitumor activity towards L1210 leukemia in mice were compared with those of complexes containing differently substituted aromatic acid hydrazides. Some of the complexes exhibited antineoplastic activity. N o correlation betw een the in vitro cytotoxicity and the in vivo antitumor activity was found. H owever, there was a relationship between the in vitro macromolecular synthesis inhibition profile and the in vivo antineoplastic effect, similar to that of cisplatin. On the other hand, only agents containing one ammine ligand were active in vivo. The substitution o f the aromatic ring by a cycloalkane residue increased significantly the antitumor effect, with [Pt(NH3)(chcah)Cl2] being the most active compound in this study. 
  Reference    Z. Naturforsch. 52c, 49 (1997); received August 1/September 18 1996 
  Published    1997 
  Keywords    Platinum(II) Complexes, Cytotoxicity, Antitumor Activity, Macromolecular Synthesis Inhibition 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0049.pdf 
 Identifier    ZNC-1997-52c-0049 
 Volume    52 
4Author    HerbertOliver Kolodziej3, HermanJ. Kayser3, Wim Woerdenbagb, Niesko Van Udenb, PrasRequires cookie*
 Title    Structure -Cytotoxicity Relationships of a Series of Natural and Semi-Synthetic Simple Coumarins as Assessed in Two Human Tumour Cell Lines  
 Abstract    The cytotoxicity of 22 natural and semi-synthetic simple coumarins was evaluated in G LC4, a human small cell lung carcinoma cell line, and in CO LO 320. a human colorectal cancer cell line, using the microculture tetrazolium (MTT) assay. With IC 50 values > 100 j.i m , following a continuous (96h) incubation, most coumarins exhibited only low cytotoxicity. Several com­ pounds, however, displayed significant potencies. As far as the structure -cytotoxicity rela­ tionship is concerned, it is conspicuous that all the potentially active natural compounds possess at least two phenolic groups in either the 6,7-or 6,8-positions. In addition, the 5-formyl-6-hydroxy substituted semi-synthetic analogue was found to be potent, reflecting the importance of at least two polar functions for high cytotoxicity. 
  Reference    Z. Naturforsch. 52c, 240—244 (1997); received November ll/December 5 1996 
  Published    1997 
  Keywords    Coumarins, Cytotoxicity, Structure-Activity Relationships, Pelargonium sidoides, Geraniaceae 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0240.pdf 
 Identifier    ZNC-1997-52c-0240 
 Volume    52 
5Author    TetsuyaM. Atsuno3, Masahiro Saitob, YasuyukiM. Atsumotob, JunjiM. OrikawabRequires cookie*
 Title    A New Benzo-y-pyran Derivative Isolated from Propolis  
 Abstract    The methanol extract of Brazilian propolis was fractionated by HPLC, based on human hepatocellular carcinoma (HuH 13) cell cytotoxicity assay. A new benzo-y-pyran derivative (PM-3) with a molecular formula of Q 9 H 2 2 O3 (MW: 298.38) was isolated. The structure of this colorless compound was determined as 3-[2-dimethyl-8-(3-methyl-2-butenyl) benzopy-ran]-6 -propenoic acid. This compound was chemically synthesized by cyclisation of artepillin C (3-[4-hydroxy-3,5-bis (3-methyl-2-butenyl) phenyl]-2-propenoic acid). 
  Reference    Z. Naturforsch. 53c, 1037—1039 (1998); received July 15/September 14 1998 
  Published    1998 
  Keywords    Propolis, Benzopyran Derivative, Artepillin C, Cytotoxicity 
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 TEI-XML for    default:Reihe_C/53/ZNC-1998-53c-1037.pdf 
 Identifier    ZNC-1998-53c-1037 
 Volume    53 
6Author    O. Spring, J. Kupka, B. M. Aier, A. HagerRequires cookie*
 Title    Helianthus annuus: Antimicrobial and Cytotoxic Properties; Influence on DNA, RNA, and Protein Synthesis  
 Abstract    Sesquiterpene lactones, produced in light and capable o f inhibiting auxin-induced elongation growth o f coleoptile and hypocotyl segments, were isolated from young leaves o f Helianthus annuus (Spring and Hager, Planta in press, 1982). These com pounds have an antibiotic effect on gram-negative and gram -positive bacteria as 
  Reference    Z. Naturforsch. 37c, 1087—1091 (1982); received August 31 1982 
  Published    1982 
  Keywords    Helianthus annuus, C om positae, Sesquiterpene Lactones, Antimicrobial Activity, Cytotoxicity 
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 TEI-XML for    default:Reihe_C/37/ZNC-1982-37c-1087.pdf 
 Identifier    ZNC-1982-37c-1087 
 Volume    37 
7Author    TetsuyaM. AtsunoRequires cookie*
 Title    A New Clerodane Diterpenoid Isolated from Propolis  
 Abstract    A physiologically active substance has been isolated from Brazilian propolis and charac­ terized as a new clerodane diterpenoid, as indicated by human hepatocellular carcinoma HuH 13 cell cytotoxicity assays. This compound inhibited growth of the hepatom a cells at a concentration around 10 [ig/ml and arrested the tumor cells at S phase as revealed by flow cytometry. A t higher concentrations it exerted lethal damage. The compound showed cyto­ toxicity on human lung carcinoma HLC-2, HeLa, KB and rat W 3 Y cells, whereas human diploid foreskin and primary rabbit kidney cells were less affected. 
  Reference    Z. Naturforsch. 50c, 93—9 (1995); received August 5/October 18 1994 
  Published    1995 
  Keywords    Propolis, Clerodane D iterpenoid, Tumor Cells, Flow Cytometry, Colcemid, Cytotoxicity 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0093.pdf 
 Identifier    ZNC-1995-50c-0093 
 Volume    50 
8Author    TetsuyaM. Atsuno3, YasuyukiM. Atsum Otob, Masahiro Saitob, JunjiM. OrikawabRequires cookie*
 Title    Isolation and Characterization of Cytotoxic Diterpenoid Isomers from Propolis  
 Abstract    The methanol extract of Brazilian propolis was frac­ tionated by HPLC, based on HuH13 (human hepatocel­ lular carcinoma) cell cytotoxicity assay. Two isomers of diterpenoid with a molecular formula of C20H 30O 3 (MW: 318.46) were isolated. The structures of these colorless compounds were determined as clerodane diterpenoids (I, 15-oxo-3, 13Z-kolavadien-17-oic acid; II, 15-oxo-3Z, ISf-kolavadien-n-oic acid). 
  Reference    Z. Naturforsch. 52c, 702—704 (1997); received March 27/May 12 1997 
  Published    1997 
  Keywords    Propolis, Clerodane Diterpenoid, N aphthalene Carbox-ylic Acid Derivative, Tumor Cells, Cytotoxicity 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0702_n.pdf 
 Identifier    ZNC-1997-52c-0702_n 
 Volume    52