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'Cytotoxic' in keywords Facet   section ZfN Section C  [X]
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1997 (1)
1982 (1)
1Author    TimM. Anke, Bruno-MaxG. Iannetti, Wolfgang SteglichRequires cookie*
 Title    Antibiotika aus Basidiomyceten, XV [1]. l-Hydroxy-2-nonin-4  
 Abstract    on, ein antifungischer und cytotoxischer Metabolit aus Ischnoderma benzoinum (Wahl.) Karst. Antibiotics from Basidiomycetes. XV [1]. l-Hydroxy-2-nonyn-4-one, an Antifungal and Cytotoxic M etabolite from Ischnoderma benzoinum (W ahl.) Karst. A new antibiotic, 1-hydroxy-2-nonyn-4-one (1), has been isolated from submerged cultures of several strains of Ischnoderma benzoinum. The compound exhibits high inhibitory activity against yeasts and filamentous fungi at concentrations o f 1 -5 ng/ml. D N A , RNA, and protein syntheses in cells of the ascitic form o f Ehrlich carcinoma are strongly inhibited by the same concentrations. 
  Reference    Z. Naturforsch. 37c, 1—4 (1982); received October 31 1981 
  Published    1982 
  Keywords    Acetylenic Metabolite, Antifungal, Cytotoxic 
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 TEI-XML for    default:Reihe_C/37/ZNC-1982-37c-0001.pdf 
 Identifier    ZNC-1982-37c-0001 
 Volume    37 
2Author    Eckhard Thines3, HeidrunA. Nke3-, Wolfgang Steglichb, Olov SternercRequires cookie*
 Title    New Botrydial Sesquiterpenoids from Hymenoscyphus epiphyllus  
 Abstract    Four new botrydial derivatives, hymendial (1), 7a-hydroxydihydrobotrydial (2), 701-hy­ droxy-10-0-methyldihydrobotrydial (4), and 7a-acetoxy-15a-methoxy-10-0-methyl-dihydro-botrydial (5) were isolated together with dihydrobotrydial (3) from the culture fluid of the ascomycete Hymenoscyphus epiphyllus. In addition, cytochalasin H (6a), 18-deoxycytocha-lasin H (6b) and (+)-mellein (7) were produced by this fungus. Hymendial (1), possessing an a, ß-unsaturated dialdehyde functionality, exhibits antimicrobial and cytotoxic activities and is mutagenic in the Ames Salmonella assay. 
  Reference    Z. Naturforsch. 52c, 413—420 (1997); received April 22/June 6 1997 
  Published    1997 
  Keywords    Hymenoscyphus epiphyllus, Botrydial Derivatives, Antimicrobial, Cytotoxic, Mutagenic 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0413.pdf 
 Identifier    ZNC-1997-52c-0413 
 Volume    52