| | 1 | Author
| TimM. Anke, Bruno-MaxG. Iannetti, Wolfgang Steglich | Requires cookie* | | | Title
| Antibiotika aus Basidiomyceten, XV [1]. l-Hydroxy-2-nonin-4  | | | | Abstract
| on, ein antifungischer und cytotoxischer Metabolit aus Ischnoderma benzoinum (Wahl.) Karst. Antibiotics from Basidiomycetes. XV [1]. l-Hydroxy-2-nonyn-4-one, an Antifungal and Cytotoxic M etabolite from Ischnoderma benzoinum (W ahl.) Karst. A new antibiotic, 1-hydroxy-2-nonyn-4-one (1), has been isolated from submerged cultures of several strains of Ischnoderma benzoinum. The compound exhibits high inhibitory activity against yeasts and filamentous fungi at concentrations o f 1 -5 ng/ml. D N A , RNA, and protein syntheses in cells of the ascitic form o f Ehrlich carcinoma are strongly inhibited by the same concentrations. | | | |
Reference
| Z. Naturforsch. 37c, 1—4 (1982); received October 31 1981 | | | |
Published
| 1982 | | | |
Keywords
| Acetylenic Metabolite, Antifungal, Cytotoxic | | | |
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| | | | | TEI-XML for
| default:Reihe_C/37/ZNC-1982-37c-0001.pdf | | | | Identifier
| ZNC-1982-37c-0001 | | | | Volume
| 37 | |
| 2 | Author
| Eckhard Thines3, HeidrunA. Nke3-, Wolfgang Steglichb, Olov Sternerc | Requires cookie* | | | Title
| New Botrydial Sesquiterpenoids from Hymenoscyphus epiphyllus | | | | Abstract
| Four new botrydial derivatives, hymendial (1), 7a-hydroxydihydrobotrydial (2), 701-hy droxy-10-0-methyldihydrobotrydial (4), and 7a-acetoxy-15a-methoxy-10-0-methyl-dihydro-botrydial (5) were isolated together with dihydrobotrydial (3) from the culture fluid of the ascomycete Hymenoscyphus epiphyllus. In addition, cytochalasin H (6a), 18-deoxycytocha-lasin H (6b) and (+)-mellein (7) were produced by this fungus. Hymendial (1), possessing an a, ß-unsaturated dialdehyde functionality, exhibits antimicrobial and cytotoxic activities and is mutagenic in the Ames Salmonella assay. | | | |
Reference
| Z. Naturforsch. 52c, 413—420 (1997); received April 22/June 6 1997 | | | |
Published
| 1997 | | | |
Keywords
| Hymenoscyphus epiphyllus, Botrydial Derivatives, Antimicrobial, Cytotoxic, Mutagenic | | | |
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| default:Reihe_C/52/ZNC-1997-52c-0413.pdf | | | | Identifier
| ZNC-1997-52c-0413 | | | | Volume
| 52 | |
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