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'Cytotoxic Activity' in keywords Facet   section ZfN Section C  [X]
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1996 (1)
1995 (1)
1Author    Brigitte Simona, Timm Anke3, U. Andersb, M. Neuhausb, F. HansskebRequires cookie*
 Title    Collybial, a New Antibiotic Sesquiterpenoid from Collybia confluens (Basidiomycetes)  
 Abstract    A new antibiotic was isolated from fermentations of an american strain of Collybia con­ fluens. Its structure was elucidated by spectroscopic methods as 2,10,10-trim ethal-4-oxo-tri-cyclo[]undec-6-en-carbaldehyde (with the relative stereo chemistry IS, 2 R. 5 R. 9 R) (1). The inhibitor, which was named collybial, is structurally related to koraiol, a sesquiter­ penoid isolated from Pinus koraiensis (Khan V. A . (1979), Khim. Prir. Soedin 5, 6 5 2 -6 5 8). Collybial inhibited the growth of Gram-positive bacteria at concentrations starting from 21.5 | i m . The propagation of vesicular stomatitis virus (V SV) in baby hamster kidney (B H K -21) cells was inhibited by 21.5 [.i m collybial. Cytotoxic effects on B H K cells were observed at 5 fold higher concentrations. 
  Reference    Z. Naturforsch. 50c, 173 (1995); received O ctober 12/Novem ber 11 1994 
  Published    1995 
  Keywords    Collybia confluens, Basidiomycetes, Antibiotic, Antiviral, Cytotoxic Activity 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0173.pdf 
 Identifier    ZNC-1995-50c-0173 
 Volume    50 
2Author    HermanJ W Oerdenbag3, L. R. En Ee, L. U. Tkea, ReinB., JanF. Sa, Stevens3, Ron Hulstb, WimH. Kruizingab, You-Ping Zhuc, ElizabethT E Lem A3, Henk Hendriks3, Wim Van, U. Den3, Niesko Pras3Requires cookie*
 Title    Isolation of Two Cytotoxic Diterpenes from the Fern Pteris multifida  
 Abstract    From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) two diterpenes, ent-kaurane-2ß,16a-diol and e«f-kaur-16-ene-2ß,15a-diol, were isolated by repeated column chromatography using silica gel and silica gel impregnated with silver nitrate. The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells. 
  Reference    Z. Naturforsch. 51c, 635 (1996); received March 6 /M ay 28 1996 
  Published    1996 
  Keywords    Pteris multifida, Polypodiaceae, Ferns, £>zf-kaurane Diterpenes, Cytotoxic Activity 
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 TEI-XML for    default:Reihe_C/51/ZNC-1996-51c-0635.pdf 
 Identifier    ZNC-1996-51c-0635 
 Volume    51