| | 1 | Author
| Brigitte Simona, Timm Anke3, U. Andersb, M. Neuhausb, F. Hansskeb | Requires cookie* | | | Title
| Collybial, a New Antibiotic Sesquiterpenoid from Collybia confluens (Basidiomycetes)  | | | | Abstract
| A new antibiotic was isolated from fermentations of an american strain of Collybia con fluens. Its structure was elucidated by spectroscopic methods as 2,10,10-trim ethal-4-oxo-tri-cyclo[7.2.0.025]undec-6-en-carbaldehyde (with the relative stereo chemistry IS, 2 R. 5 R. 9 R) (1). The inhibitor, which was named collybial, is structurally related to koraiol, a sesquiter penoid isolated from Pinus koraiensis (Khan V. A . (1979), Khim. Prir. Soedin 5, 6 5 2 -6 5 8). Collybial inhibited the growth of Gram-positive bacteria at concentrations starting from 21.5 | i m . The propagation of vesicular stomatitis virus (V SV) in baby hamster kidney (B H K -21) cells was inhibited by 21.5 [.i m collybial. Cytotoxic effects on B H K cells were observed at 5 fold higher concentrations. | | | |
Reference
| Z. Naturforsch. 50c, 173 (1995); received O ctober 12/Novem ber 11 1994 | | | |
Published
| 1995 | | | |
Keywords
| Collybia confluens, Basidiomycetes, Antibiotic, Antiviral, Cytotoxic Activity | | | |
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| default:Reihe_C/50/ZNC-1995-50c-0173.pdf | | | | Identifier
| ZNC-1995-50c-0173 | | | | Volume
| 50 | |
| 2 | Author
| HermanJ W Oerdenbag3, L. R. En Ee, L. U. Tkea, ReinB., JanF. Sa, Stevens3, Ron Hulstb, WimH. Kruizingab, You-Ping Zhuc, ElizabethT E Lem A3, Henk Hendriks3, Wim Van, U. Den3, Niesko Pras3 | Requires cookie* | | | Title
| Isolation of Two Cytotoxic Diterpenes from the Fern Pteris multifida | | | | Abstract
| From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) two diterpenes, ent-kaurane-2ß,16a-diol and e«f-kaur-16-ene-2ß,15a-diol, were isolated by repeated column chromatography using silica gel and silica gel impregnated with silver nitrate. The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells. | | | |
Reference
| Z. Naturforsch. 51c, 635 (1996); received March 6 /M ay 28 1996 | | | |
Published
| 1996 | | | |
Keywords
| Pteris multifida, Polypodiaceae, Ferns, £>zf-kaurane Diterpenes, Cytotoxic Activity | | | |
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| default:Reihe_C/51/ZNC-1996-51c-0635.pdf | | | | Identifier
| ZNC-1996-51c-0635 | | | | Volume
| 51 | |
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