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1998 (1)
1Author    Julia Yanevaa, Jordanka Zlatanova30Requires cookie*
 Title    The Electrophoretic Separation of Curved Cisplatin-Modifled DNA Fragments on Polyacrylamide Gels Is Dependent on the Voltage Gradient  
 Abstract    Polyacrylamide gel electrophoresis has been widely used to study DNA fragments containing sequence-de-pendent curvature. The anomalous electrophoretic be­ havior of curved DNA fragments on such gels allows their separation from straight fragments of the same length. H ere we dem onstrate that polyacrylamide gels can be successfully used to resolve DNA fragments m od­ ified at a single site by the antitum or drug ds-diam-m inedichloroplatinum (II) (ds-DDP, cisplatin) from their unmodified counterparts. However, the resolution strongly depends on the voltage gradient, being com­ pletely lost when it drops below a certain threshold level. The param eters of the electric field do not affect separation of 'norm al' DNA fragments of comparable length. 
  Reference    Z. Naturforsch. 53c, 921—923 (1998); received April 27/May 12 1998 
  Published    1998 
  Keywords    Cisplatin, Curved DNA, Electric Field, Electrophoresis, Polyacrylamide Gels 
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 TEI-XML for    default:Reihe_C/53/ZNC-1998-53c-0921_n.pdf 
 Identifier    ZNC-1998-53c-0921_n 
 Volume    53