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1982 (1)
1978 (1)
1Author    Reinhold Tacke, Roland NiednerRequires cookie*
 Title    Sila-Pharmaka, 9. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, I Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, I  
 Abstract    Organosilicon compounds 8, 9 and 10 with potential curare-like action and their precursors 5, 6 and 7 were synthesized for the first time. 5-10 were characterized by their physical and chemical properties, and their structures were confirmed by analyses, 1 H NMR and mass spectroscopy (only for 5-7). The pharmacological and toxicological data of 8, 9 and 10 are reported. 
  Reference    Z. Naturforsch. 33b, 412—416 (1978); eingegangen am 3. Februar 1978 
  Published    1978 
  Keywords    Silicon Compounds, Pharmacological Properties, Toxicological Properties, Curare-Like Activity 
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 TEI-XML for    default:Reihe_B/33/ZNB-1978-33b-0412.pdf 
 Identifier    ZNB-1978-33b-0412 
 Volume    33 
2Author    Reinhold Tacke, Haryanto Linoh, MoayadT. Attar-Bashi, WilliamS. Sheldrick, Ludger Ernst, Roland Niedner, Joachim FrohneckeRequires cookie*
 Title    Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III Sila-Pharmaca, 26th Communication [1] Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, III  
 Abstract    The potentially curare-hke silicon compounds 8a-Sf were synthesized and investigated with respect to their structure-activity relationships. The conformations of the com-pounds in the solid state and in solution were studied by X-ray diffraction analysis (8a-8e) and *H NMR spectroscopy (8a-8f), respectively. The muscle relaxing properties of 8a-8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 A model" for neuromuscular blocking agents. Einführung 
  Reference    Z. Naturforsch. 37b, 1461—1471 (1982); eingegangen am 19. April 1982 
  Published    1982 
  Keywords    Silicon Compounds, Curare-Like Activity, X-ray, Conformational Analyses, Structure-Activity Relationships 
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 TEI-XML for    default:Reihe_B/37/ZNB-1982-37b-1461.pdf 
 Identifier    ZNB-1982-37b-1461 
 Volume    37