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2000 (1)
1978 (2)
1Author    Katarzyna Woźniak, Zofia WalterRequires cookie*
 Title    Induction of DNA-Protein Cross-Links by Platinum Compounds  
 Abstract    The differences between cis-and mws-diamminedichloroplatinum II (DDP) in forming DNA-protein cross-links in isolated human lymphocytes were investigated. Both cis-and rra/75-DDP can induce DNA-protein cross-links. We show that cis-DDP forms complexes between D N A and proteins faster than trans-DDP. This results from an increase in the quan­ tity of D NA and platinum together with an increase in drug concentration. Under the same conditions trans-DDP causes a decrease in DNA-forming complexes with proteins. After a 12 h incubation of lymphocytes we observe a similar level of DNA in DNA-protein cross­ links induced by D D P isomers, but more platinum appears in complexes induced by trans-DDP. The results obtained demonstrate that the antitumor drug -ds-DDP and the clinically ineffective trans-DDP induce links between D N A and proteins in a different manner. We suggest that the therapeutic activity of ds-DDP can in part arise from rapidly forming DNA-protein complexes which can destroy the most important cellular processes, such as replica­ tion and transcription. 
  Reference    Z. Naturforsch. 55c, 731—736 (2000); received March 30/June 26 2000 
  Published    2000 
  Keywords    Lymphocytes, DNA-Protein, Cross-Links 
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 TEI-XML for    default:Reihe_C/55/ZNC-2000-55c-0731.pdf 
 Identifier    ZNC-2000-55c-0731 
 Volume    55 
2Author    Eckhard SchlimmeRequires cookie*
 Title    Darstellung von (9-ß-D-Ribofuranosyl)-s-triazolo-[ 1,2a]-purin-6-on durch Cyclisierung von N-l-Aminoguanosin Preparation of (9-/3-D-Ribofuranosyl)-s-triazolo-[l,2a]-purine-6-one by Cyclization of N-l-Amino Guanosine  
  Reference    Z. Naturforsch. 33c, 326 (1978); eingegangen am 22. März 1978 
  Published    1978 
  Keywords    s-triazolo-[l, 2a]-purine-6-one, 13C-NMR, 'H-NMR, Cross Links 
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 TEI-XML for    default:Reihe_C/33/ZNC-1978-33c-0326.pdf 
 Identifier    ZNC-1978-33c-0326 
 Volume    33 
3Author    H. Wesch, R. Jonak, H. Nemetschek-Gansler, H. Riedl, Th NemetschekRequires cookie*
 Title    Der Einfluß von D-Penicillamin auf den Gehalt einiger Organe an Spurenelementen sowie auf die mechanischen Eigenschaften von Kollagen Trace Elements in Several Organs and Mechanical Properties of Collagen under the Influence of D-Penicillamin  
 Abstract    The content of trace elements in several organs of rats under the influence of D-penicillamine (D-PA) was investigated by the neutronactivation-analysis. It could be shown an diminution of Cu, and Co under D-PA-treatment, the content of Fe, Mn, Rb and Zn was not influenced. The investigat­ ed organs didn't show any submicroscopic alterations under D-PA. On isolated collagen fibrils of tail tendon was seen a significantly diminuition of E-moduls. In accordance with Siegel the principal effect of D-PA is thought to block the synthesis of functional groups from Schiff-base crosslink precursors but not to inhibit lysyloxidase by loss of Cu-ions of connective tissue. The thermostability of D-PA influenced fibrils is changed in stretched state only and will be due to the lack of crosslink Schiff-bases; where as the shrinking point of not stretched fibrils shows only aging dependent changes. 
  Reference    Z. Naturforsch. 33c, 346 (1978); eingegangen am 17. März 1978 
  Published    1978 
  Keywords    D-Penicillamin, Trace Elements, Electron Microscopy, Biosynthesis, Cross-Links, Mechanical Properties of Collagen 
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 TEI-XML for    default:Reihe_C/33/ZNC-1978-33c-0346.pdf 
 Identifier    ZNC-1978-33c-0346 
 Volume    33