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'Coumarins' in keywords Facet   section ZfN Section C  [X]
Facet   Publication Year 1999  [X]
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1Author    Oliver Kayser, H. Erbert KolodziejRequires cookie*
 Title    Antibacterial Activity of Simple Coumarins: Structural Requirements for Biological Activity  
 Abstract    The antibacterial activity of a series of simple coumarins was evaluated against 8 microor­ ganisms, including three Gram-positive (Staphylococcus aureus, beta-hemolytic Streptococcus and Streptococcus pneum oniae) and five Gram-negative bacteria (Escherichia coli, Klebsiella pneum oniae, Pseudom onas aeruginosa, Proteus mirabilis and H aemophilus influenzae), using the microdilution broth method. The coumarins tested showed broad diversity regarding growth inhibitory activity with minimum inhibitory concentrations ranging from 0.9 to >12.4 (j.M . This study, presenting the first systematic analysis of structure-activity relationships among this group of coumarins, revealed some interesting structural requirements. While coumarins with a methoxy function at C-7 and, if present, an OH group at either the C-6 or C-8 position are invariably effective against the spectrum of tested standard bacteria (Gram-negative microorganisms including the Gram-positive bacterium Staphylococcus aureus), the presence of an aromatic dimethoxy arrangement is apparently favourable against those mi­ croorganisms which require special growth factors (beta-hemolytic Streptococcus, Streptococ­ cus pneum oniae and Haem ophilus influenzae). A combination of these structural features, two methoxy functions and at least one additional phenolic group as reflected by the highly oxygenated coumarins, identify promising candidates with antibacterial broad-spectrum ac­ tivity. 
  Reference    Z. Naturforsch. 54c, 169—174 (1999); received November 11/December 8 1998 
  Published    1999 
  Keywords    Coumarins, Antibacterial Activity, Structure-Activity Relationships 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0169.pdf 
 Identifier    ZNC-1999-54c-0169 
 Volume    54