| | 1 | Author
| HerbertOliver Kolodziej3, HermanJ. Kayser3, Wim Woerdenbagb, Niesko Van Udenb, Pras | Requires cookie* | | | Title
| Structure -Cytotoxicity Relationships of a Series of Natural and Semi-Synthetic Simple Coumarins as Assessed in Two Human Tumour Cell Lines  | | | | Abstract
| The cytotoxicity of 22 natural and semi-synthetic simple coumarins was evaluated in G LC4, a human small cell lung carcinoma cell line, and in CO LO 320. a human colorectal cancer cell line, using the microculture tetrazolium (MTT) assay. With IC 50 values > 100 j.i m , following a continuous (96h) incubation, most coumarins exhibited only low cytotoxicity. Several com pounds, however, displayed significant potencies. As far as the structure -cytotoxicity rela tionship is concerned, it is conspicuous that all the potentially active natural compounds possess at least two phenolic groups in either the 6,7-or 6,8-positions. In addition, the 5-formyl-6-hydroxy substituted semi-synthetic analogue was found to be potent, reflecting the importance of at least two polar functions for high cytotoxicity. | | | |
Reference
| Z. Naturforsch. 52c, 240—244 (1997); received November ll/December 5 1996 | | | |
Published
| 1997 | | | |
Keywords
| Coumarins, Cytotoxicity, Structure-Activity Relationships, Pelargonium sidoides, Geraniaceae | | | |
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| default:Reihe_C/52/ZNC-1997-52c-0240.pdf | | | | Identifier
| ZNC-1997-52c-0240 | | | | Volume
| 52 | |
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