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'Coumarins' in keywords Facet   section ZfN Section C:Volume 052  [X]
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1997 (1)
1Author    HerbertOliver Kolodziej3, HermanJ. Kayser3, Wim Woerdenbagb, Niesko Van Udenb, PrasRequires cookie*
 Title    Structure -Cytotoxicity Relationships of a Series of Natural and Semi-Synthetic Simple Coumarins as Assessed in Two Human Tumour Cell Lines  
 Abstract    The cytotoxicity of 22 natural and semi-synthetic simple coumarins was evaluated in G LC4, a human small cell lung carcinoma cell line, and in CO LO 320. a human colorectal cancer cell line, using the microculture tetrazolium (MTT) assay. With IC 50 values > 100 j.i m , following a continuous (96h) incubation, most coumarins exhibited only low cytotoxicity. Several com­ pounds, however, displayed significant potencies. As far as the structure -cytotoxicity rela­ tionship is concerned, it is conspicuous that all the potentially active natural compounds possess at least two phenolic groups in either the 6,7-or 6,8-positions. In addition, the 5-formyl-6-hydroxy substituted semi-synthetic analogue was found to be potent, reflecting the importance of at least two polar functions for high cytotoxicity. 
  Reference    Z. Naturforsch. 52c, 240—244 (1997); received November ll/December 5 1996 
  Published    1997 
  Keywords    Coumarins, Cytotoxicity, Structure-Activity Relationships, Pelargonium sidoides, Geraniaceae 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0240.pdf 
 Identifier    ZNC-1997-52c-0240 
 Volume    52