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1997 (1)
1Author    M. Anuela Wagner3, R. Obert Ruloffb, EberhardH. Oyerb, Wilfried Gründer3Requires cookie*
 Title    New Gadolinium Complexes as Magnetic Resonance Imaging -Contrast Agents  
 Abstract    We have investigated the physicochemical and paramagnetic properties of the new gado­ linium complexes of N-(pyrid-2-yl-m ethyl)-ethylenediam ine-N,N',N'-triacetic acid (Gd-PED TA) and N -tris(2-am in oeth yl)am in e-N \N \N ",N ",N "\N '"-hexaacetic acid (Gd-TTA H A). The relaxivities as well as the thermodynamic and conditional stability constants of these complexes with respect to the physiological relevance were determined and discussed in comparison with the commercially available gadolinium(III) diethylenetriaminpentaacetic acid/ gadopentate dimeglumine (G d-DTPA, Magnevist®). In case of Gd-TTAHA a twofold higher relaxivity and a com plex stability similar to Gd-DTPA were determined. It is shown, that lower concentrations o f G d-TTA H A are sufficient for the same signal enhancement in the Tt-weighted MR image compared with Gd-DTPA and, thus, the use of the new contrast agent Gd-TTAHA should diminish risks for health. Therefore, Gd-TTAHA might be used potentially as a new contrast agent for clinical MRI application. 
  Reference    Z. Naturforsch. 52c, 508 (1997); received April 23/June 4 1997 
  Published    1997 
  Keywords    Gadolinium(III) Complexes, Contrast Agents, Relaxivities, Complex Stability Constants, Magnetic Resonance Imaging 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0508.pdf 
 Identifier    ZNC-1997-52c-0508 
 Volume    52