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1991 (1)
1977 (1)
1Author    AngelM. RelimpioRequires cookie*
 Title    Structure and Anticholinesterase Activity of Series of Ethyl Substituted Phenyl Methylphosphonates  
 Abstract    Thirty derivates from substituted-phenyl-ethyl methylphosphonates have been synthesized and their inhibiting power of acetyl-cholinesterase have been examined in vitro and in vivo. The cor­ relation between inhibition of the enzyme and electrophylic power of the substituent of the phenyl group was excellent, but when this group contains two substituents, steric factors appear to operate. The activity of these compounds has been demonstrated to be higher than their phosphate analogs. 
  Reference    (Z. Naturforsch. 32c, 760 [1977]; received June 13 1977) 
  Published    1977 
  Keywords    Cholinesterase, Methylphosphonates, Inhibitors, Biological Activity 
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 TEI-XML for    default:Reihe_C/32/ZNC-1977-32c-0760.pdf 
 Identifier    ZNC-1977-32c-0760 
 Volume    32 
2Author    Ch Heyde, M. WenzelRequires cookie*
 Title    Schweres Wasser (D 20 ) als Protektivum proteinhaltiger Arzneimittel. Beispiel: humane Cholinesterase Protein Drugs Stabilized by Heavy W ater (D 20 ). For Example: Hum an Cholinesterase  
 Abstract    Looking for a possible protective effect o f heavy water on proteins, Cholinesterase and lac­ tate dehydrogenase in com bination with D 20 and further protective substances were exposed to a temperature o f 60 °C (for 10 min) and about 45 °C (for several days). In combination with glycerine there resulted an additive protective effect; with NaCl and/or albumin being added the individual effects raised to a higher level. In the cold D 20 protects Cholinesterase only against acid denaturation, but in com bination with warmth also against basic dena-turation. 
  Reference    Z. Naturforsch. 46c, 789—7 (1991); eingegangen am 19. Februar 1991 
  Published    1991 
  Keywords    Heavy Water, Protein Drugs, Stabilization, Com binations, Cholinesterase 
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 TEI-XML for    default:Reihe_C/46/ZNC-1991-46c-0789.pdf 
 Identifier    ZNC-1991-46c-0789 
 Volume    46