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'Cell Suspension Cultures' in keywords Facet   Publication Year 1979  [X]
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1Author    H. Ans-M, Artin SchiebelRequires cookie*
 Title    A Model Mechanism for the Enzymatic Synthesis of Lupin Alkaloids  
 Abstract    A crude enzyme preparation obtained from cell suspension cultures o f Lupinus polyphyllus cat­ alyzes the pyruvate dependent conversion o f cadaverine into the tetracyclic lupin alkaloids. As the first reaction product 17-oxosparteine could be identified by gas-liquid chrom atography and mass spectroscopy. In som e experiments sparteine was found additionally. A participation o f di­ amine oxidase could be ruled out. The cadaverine-pyruvate transaminating enzyme system (17-oxosparteine synthase) catalyzes the formation o f 17-oxosparteine from three cadaverine units without releasing free intermediates. These results are inconsistent with the hypothetical m echa­ nism thus far formulated for the lupin alkaloid biosynthesis. A new enzym atic model mechanism is proposed regarding both the results o f the enzymatic experiments and those o f the in vivo tracer studies. 
  Reference    Z. Naturforsch. 34c, 704—708 (1979); received June 8 1979 
  Published    1979 
  Keywords    Lupinus polyphyllus, Cell Suspension Cultures, Q uinolizidine Alkaloids, Enzymatic Synthesis, Biosynthetic Model Mechanism 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-0704.pdf 
 Identifier    ZNC-1979-34c-0704 
 Volume    34