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1988 (1)
1Author    Daniela Vedaldi, Sergio Caffieri, Giorgia Miolo, Francesco Dall 'acqua, Paola ArslanRequires cookie*
 Title    Dark and Photohemolysis of Erythrocytes by Furocoumarins  
 Abstract    It has been shown that various furocoumarins are able to cause dark hemolysis in red blood cells (RBC). However, this effect is evident only at relatively high furocoumarin concentrations (4.6 x 10~ 4 M) -much higher than those used in photosensitization experiments or photo-chemotherapeutic treatments. Among the various furocoumarins examined in this study, only psoralen (Ps) and 3-carbethoxy-psoralen (3-CPs) showed strong photohemolytic effects, while the other compounds revealed little or no activity. This fact indicates that Ps and 3-CPs are able to induce selective damage to the cell membrane of RBC. By pre-irradiating furocoumarin in ethanol or isotonic saline solutions and adding the irradiated solutions to a RBC suspension, hemolysis was observed in various compounds. The products of photolysis which form during pre-irradiation may be responsible, in terms of hemolysis, for toxic effects on RBC. 
  Reference    Z. Naturforsch. 43c, 888—892 (1988); received August 2 1988 
  Published    1988 
  Keywords    Furocoumarins, Hemolysis, Photosensitization, Cell Membrane Damage, Photochemotherapy 
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 TEI-XML for    default:Reihe_C/43/ZNC-1988-43c-0888.pdf 
 Identifier    ZNC-1988-43c-0888 
 Volume    43