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1996 (1)
1Author    Janina Kuczera3, Henryk Chojnackib, TeresaE. Kral3, Stanislaw Przestalski3Requires cookie*
 Title    Effect of Amphiphilic Cationic Compounds on Calcium Ion Desorption from Lecithin Liposome Membranes. Kinetic Studies and Quantum Chemical Calculations  
 Abstract    The effect o f four amphiphilic cationic compounds that differ in their polar head properties on the kinetics of calcium ion desorption from unilamellar lecithin liposom e membranes has been studied. The compounds under investigation were: N-benzyl-N,N-dimethyl-N-tetradecy-lammonium chloride (B D T A), N-methyl-N-tetradecylmorpholinium bromide (M TM), N-methyl-N-dodecyloxym ethylenem orpholinium chloride (M D O M) and N,N,N-trimethyl-N-te-tradecylammonium bromide (TM TA). Kinetic constants were determined using the three-compartmental analysis for isotopic labels. For the above m entioned compounds electronic structure calculations were performed and point charges and dipole m om ents of the molecules determined by using quantum chemis­ try methods. It was found that the rate of desorption increases with increasing concentration of the compounds studied, and effectiveness of the compounds follows the sequence: BDTA >M TM >TM TA >M DO M . For dipole moments the sequence obtained is somewhat different, namely: BDTA>M TM >M DO M >TM TA. Apparently, the differences in the effec­ tiveness of action of the compounds in the calcium desorption process follow not only from the values of dipole m om ents o f their polar heads but also from the values of point charges on som e atoms and from steric properties. 
  Reference    Z. Naturforsch. 51c, 219 (1996); received November 7 1995/January 3 1996 
  Published    1996 
  Keywords    Cationic Amphiphiles, Liposom es, Calcium Ion Desorption, Quantum Chemical Calculations 
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 TEI-XML for    default:Reihe_C/51/ZNC-1996-51c-0219.pdf 
 Identifier    ZNC-1996-51c-0219 
 Volume    51