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'Carbon Tetrachloride' in keywords
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2001 (2)
1975 (1)
1Author    Requires cookie*
 Title    New Synthesis of N-phosphoranylidene-sulfuric Aeid Amides, -sulfuric Acid Alkylester Amides, -fluoro- sulfuric Acid Amide and -alkylsulfonamide, I I 1-2  
 Abstract    By reaction of triphenylphosphine and carbon tetrachloride with methane sulfon­ amide (la) and the sulfamic acid derivatives 
  Reference    (Z. Naturforsch. 30b, 134—135 [1975]; eingegangen am 2. Oktober 1974) 
  Published    1975 
  Keywords    Triphenylphosphine, Carbon Tetrachloride, Sulfamic Acid Derivatives, Methane Sulfonamide 
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 TEI-XML for    default:Reihe_B/30/ZNB-1975-30b-0134_n.pdf 
 Identifier    ZNB-1975-30b-0134_n 
 Volume    30 
2Author    Meinrad Boll, LutzW D Weber, Eberhard Becker, Andreas StampflRequires cookie*
 Title    Pathogenesis of Carbon Tetrachloride-Induced Hepatocyte Injury Bioactivation of CC14 by Cytochrome P450 and Effects on Lipid Homeostasis  
 Abstract    The CCl4-induced development of liver damage was studied in monolayer cultures of pri­ mary rat hepatocytes: (1) CC14 caused accumulation of triglycerides in hepatocytes following cytochrome P450 induction with ß-naphthoflavone or metyrapone. Ethanol or a high dose of insulin plus triio­ dothyronine had the same effect. (2) CC14 increased the synthesis of fatty acids and triglycer­ ides and the rate of lipid esterification. Cholesterol and phospholipid synthesis from acetate was also increased. (3) CC14 reduced ß-oxidation of fatty acids as assessed by C 0 2-release and ketone body formation. Hydrolysis of triglycerides was also reduced. (4) The content of unsaturated fatty acids in microsomal lipids was decreased by almost 50% after incubation with CCI4, while saturated fatty acids increased slightly. (5) CC14 exerted a pronounced inhib­ itory effect on the exocytosis of macromolecules (albumin), but did not affect secretion of bile acids from hepatocytes. 
  Reference    Z. Naturforsch. 56c, 111—121 (2001); received July 28/September 14 2000 
  Published    2001 
  Keywords    Liver Damage, Carbon Tetrachloride, Cytochrome P450 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0111.pdf 
 Identifier    ZNC-2001-56c-0111 
 Volume    56 
3Author    M. Einrad Boll, LutzW D Weber, E.Berhard Becker, Andreas StampflRequires cookie*
 Title    Hepatocyte Damage Induced by Carbon Tetrachloride: Inhibited Lipoprotein Secretion and Changed Lipoprotein Composition  
 Abstract    Changes of lipoprotein secretion and composition in response to CC14 treatment were studied in monolayer cultures of rat primary hepatocytes. (1) CC14 decreased secretion of very low density lipoproteins (V L D L) by about 85%, while high density lipoprotein (H D L) secretion was less affected (about 40%). The effect was concentration-dependent. (2) CC14 significantly inhibited secretion of V LD L-and H D L-asso-ciated triglycerides and cholesterol esters. V LD L-and HD L-associated cholesterol was not affected, while secretion of phospholipids was increased. (3) Hepatocytes secreted the apoli-poproteins B48, B 100, E, C, and A-I. CC14 reduced secretion of apoproteins associated with V L D L by almost 20%, and by about 75% when associated with H D L. The de novo synthesis of apolipoproteins was attenuated by CC14. (4) CC14 caused variations in the apolipoprotein composition in V L D L and HDL. CC14 intoxication of the liver affected the morphology and/or function of the lipoproteins, which drastically impaired their ability to act as transport vehicles for lipids from the liver to the circulation. 
  Reference    Z. Naturforsch. 56c, 283 (2001); received October 13/November 29 2000 
  Published    2001 
  Keywords    Liver Damage, Carbon Tetrachloride, Lipoprotein Secretion 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0283.pdf 
 Identifier    ZNC-2001-56c-0283 
 Volume    56