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1999 (1)
1991 (1)
1Author    C. Hristiane, T. Em Pête, M. Ichel Devys, M. Ichel BarbierRequires cookie*
 Title    Growth Inhibitions on Human Cancer Cell Cultures with the Indole Sulphur-Containing Phytoalexins and Their Analogues  
 Abstract    Cell growth inhibitions on human cancer cell cultures were determined for the indole sulphur-containing phy­ toalexins cyclobrassinin, brassilexin (previously isolated from vegetables o f the Cruciferae family) and their syn­ thetic analogues 5-methoxybrassilexin and hom ocyclo-brassinin. The most biologically active o f these products is brassilexin (L D 50 = 8 (ig/ml). 
  Reference    Z. Naturforsch. 46c, 706 (1991); received January 21 1991 
  Published    1991 
  Keywords    Growth Inhibition, Cancer Cells, Phytoalexins, Cruci­ fer ae 
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 TEI-XML for    default:Reihe_C/46/ZNC-1991-46c-0706_n.pdf 
 Identifier    ZNC-1991-46c-0706_n 
 Volume    46 
2Author    FrankI. Bohnenstengel3, KlausG. Steubeb, CorinnaM. Eyerb, BambangW. Nugroho3, PhamD. Hungc, LeC. Kietd, Peter Proksch3Requires cookie*
 Title    Structure Activity Relationships of Antiproliferative Rocaglamide Derivatives from Aglaia Species (Meliaceae)  
 Abstract    Eleven rocaglamide derivatives (cyclopentatetrahydrobenzofurans) and one structurally related aglain congener all isolated from different Aglaia species (Meliaceae) were tested for growth inhibiting properties using the human cancer cell lines MONO-MAC-6 and MEL-JUSO. Proliferation of both cell lines was efficiently inhibited in a dose and compound de­ pendent manner. Applying a MTT-Assay, the IC50 of the most active compound didesmethyl-rocaglamide (1) was observed at 0.002 and 0.006 [ig/ml (0.004 and 0.013 j.iM) depending on the cell line investigated. Bulky aminoacyl substituents at C-2, acetylation of the OH substitu­ ent at C-l or insertion of a OH or OMe substituent at C-3 of the rocaglamide skeleton all diminished the activity of the compounds investigated. The aglain derivative 12 was inactive up to a concentration of 3 ng/ml (4.6 [ . i m) . This loss of activity is assumed to be mainly due to the presence of a pyran ring in the aglains vs. a furan ring as found in rocaglamide derivatives. Rocaglamide derivatives may act primarily by inhibition of cell proliferation as evidenced by the absence of a significant cytotoxic effect in long-term cultures of MONO-MAC-6 cells treated with high doses of didesmethylrocaglamide. O ur data suggest that rocaglamide derivatives could exert a potential role in the treatm ent of malignant diseases and are worth to be investigated in further studies of experimental medicine and pharmacology. 
  Reference    Z. Naturforsch. 54c, 55—6 (1999); received September 28/October 21 1998 
  Published    1999 
  Keywords    Aglaia spp, Meliaceae, Rocaglamide, Cyclopentatetrahydrobenzofurans, Antiproliferative Activity, Cancer Cells, M ONO-M AC-6 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0055.pdf 
 Identifier    ZNC-1999-54c-0055 
 Volume    54