ZfN: Search Results

1	Author	C. Hristiane, T. Em Pête, M. Ichel Devys, M. Ichel Barbier	Requires cookie*
	Title	Growth Inhibitions on Human Cancer Cell Cultures with the Indole Sulphur-Containing Phytoalexins and Their Analogues
	Abstract	Cell growth inhibitions on human cancer cell cultures were determined for the indole sulphur-containing phy toalexins cyclobrassinin, brassilexin (previously isolated from vegetables o f the Cruciferae family) and their syn thetic analogues 5-methoxybrassilexin and hom ocyclo-brassinin. The most biologically active o f these products is brassilexin (L D 50 = 8 (ig/ml).
	Reference	Z. Naturforsch. 46c, 706 (1991); received January 21 1991
	Published	1991
	Keywords	Growth Inhibition, Cancer Cells, Phytoalexins, Cruci fer ae
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	TEI-XML for	default:Reihe_C/46/ZNC-1991-46c-0706_n.pdf
	Identifier	ZNC-1991-46c-0706_n
	Volume	46

2	Author	FrankI. Bohnenstengel3, KlausG. Steubeb, CorinnaM. Eyerb, BambangW. Nugroho3, PhamD. Hungc, LeC. Kietd, Peter Proksch3	Requires cookie*
	Title	Structure Activity Relationships of Antiproliferative Rocaglamide Derivatives from Aglaia Species (Meliaceae)
	Abstract	Eleven rocaglamide derivatives (cyclopentatetrahydrobenzofurans) and one structurally related aglain congener all isolated from different Aglaia species (Meliaceae) were tested for growth inhibiting properties using the human cancer cell lines MONO-MAC-6 and MEL-JUSO. Proliferation of both cell lines was efficiently inhibited in a dose and compound de pendent manner. Applying a MTT-Assay, the IC50 of the most active compound didesmethyl-rocaglamide (1) was observed at 0.002 and 0.006 [ig/ml (0.004 and 0.013 j.iM) depending on the cell line investigated. Bulky aminoacyl substituents at C-2, acetylation of the OH substitu ent at C-l or insertion of a OH or OMe substituent at C-3 of the rocaglamide skeleton all diminished the activity of the compounds investigated. The aglain derivative 12 was inactive up to a concentration of 3 ng/ml (4.6 [ . i m) . This loss of activity is assumed to be mainly due to the presence of a pyran ring in the aglains vs. a furan ring as found in rocaglamide derivatives. Rocaglamide derivatives may act primarily by inhibition of cell proliferation as evidenced by the absence of a significant cytotoxic effect in long-term cultures of MONO-MAC-6 cells treated with high doses of didesmethylrocaglamide. O ur data suggest that rocaglamide derivatives could exert a potential role in the treatm ent of malignant diseases and are worth to be investigated in further studies of experimental medicine and pharmacology.
	Reference	Z. Naturforsch. 54c, 55—6 (1999); received September 28/October 21 1998
	Published	1999
	Keywords	Aglaia spp, Meliaceae, Rocaglamide, Cyclopentatetrahydrobenzofurans, Antiproliferative Activity, Cancer Cells, M ONO-M AC-6
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	TEI-XML for	default:Reihe_C/54/ZNC-1999-54c-0055.pdf
	Identifier	ZNC-1999-54c-0055
	Volume	54