| | 1 | Author
| Janina Kuczera3, Henryk Chojnackib, TeresaE. Kral3, Stanislaw Przestalski3 | Requires cookie* | | | Title
| Effect of Amphiphilic Cationic Compounds on Calcium Ion Desorption from Lecithin Liposome Membranes. Kinetic Studies and Quantum Chemical Calculations  | | | | Abstract
| The effect o f four amphiphilic cationic compounds that differ in their polar head properties on the kinetics of calcium ion desorption from unilamellar lecithin liposom e membranes has been studied. The compounds under investigation were: N-benzyl-N,N-dimethyl-N-tetradecy-lammonium chloride (B D T A), N-methyl-N-tetradecylmorpholinium bromide (M TM), N-methyl-N-dodecyloxym ethylenem orpholinium chloride (M D O M) and N,N,N-trimethyl-N-te-tradecylammonium bromide (TM TA). Kinetic constants were determined using the three-compartmental analysis for isotopic labels. For the above m entioned compounds electronic structure calculations were performed and point charges and dipole m om ents of the molecules determined by using quantum chemis try methods. It was found that the rate of desorption increases with increasing concentration of the compounds studied, and effectiveness of the compounds follows the sequence: BDTA >M TM >TM TA >M DO M . For dipole moments the sequence obtained is somewhat different, namely: BDTA>M TM >M DO M >TM TA. Apparently, the differences in the effec tiveness of action of the compounds in the calcium desorption process follow not only from the values of dipole m om ents o f their polar heads but also from the values of point charges on som e atoms and from steric properties. | | | |
Reference
| Z. Naturforsch. 51c, 219 (1996); received November 7 1995/January 3 1996 | | | |
Published
| 1996 | | | |
Keywords
| Cationic Amphiphiles, Liposom es, Calcium Ion Desorption, Quantum Chemical Calculations | | | |
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| ZNC-1996-51c-0219 | | | | Volume
| 51 | |
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