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2001 (1)
1Author    Stylianos Tsakiris3, Christos Koromilas3, KleopatraH. SchulpisbRequires cookie*
 Title    R edu ced M g2^ A T Pase A ctivity in the H yp o­ glycem ic A d u lt R at Brain  
 Abstract    The effects of different a-D-Glucose (Glu) concentra­ tions (0 -1 6 m M) on N a+, K + -ATPase and Mg2+ -ATPase activities were investigated in homogenates of adult male rat whole brain at 37 °C. The enzyme activities were determ ined after lh preincubation with Glu. Brain N a+, K+ -ATPase was not affected by Glu different con­ centrations. On the contrary, Mg2+ -ATPase activity was considerably reduced with Glu concentrations lower than 4 m M . The enzyme was inhibited 40%, 50% or 80% with 3, 2 or 1 mM of Glu, respectively. The above results suggest: a) The various concentrations of Glu have no effect on brain N a+, K + -ATPase activity, b) The inhib­ ited brain Mg2+ -ATPase in hypoglycemia produces low intracellular Mg2+, which could modulate the activity of Mg2+ -dependent enzymes and the rates of protein syn­ thesis and growth of the cell. 
  Reference    Z. Naturforsch. 56c, 912—914 (2001); received June 26/August 8 2001 
  Published    2001 
  Keywords    Hypoglycemic Brain, Brain Mg2 +-ATPase, Brain Na+, K+ -ATPase 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0912_n.pdf 
 Identifier    ZNC-2001-56c-0912_n 
 Volume    56