| | 1 | Author
| Michael Entzeroth, Lothar Jaenicke | Requires cookie* | | | Title
| Blepharisma japonicum Synthesis of Blepharismone, the Low-Molecular Conjugation Hormone of Blepharisma japonicum  | | | | Abstract
| An effective and versatile synthesis of 5-hydroxytrypto-phane derivatives offers good access to the conjugation in ducing hormone blepharismone o f the ciliate Blepharisma japonicum and to derivatives and analogues of this biolog ically active compound. 5'-Fluoroblepharismone and 2'-des-formamidoblepharismone induce conjugation at 500 and 1200 times, respectively, the concentration of the true effector. At high concentration, however, the 2'-des-form-amido derivative desensitizes the receptor system for the natural gamone. | | | |
Reference
| Z. Naturforsch. 36c, 180 (1981); eingegangen am 20. Oktober 1980 | | | |
Published
| 1981 | | | |
Keywords
| Blepharisma japonicum, Blepharismone, Conjugation, Gamones, Hormones | | | |
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| | | | | TEI-XML for
| default:Reihe_C/36/ZNC-1981-36c-0180_n.pdf | | | | Identifier
| ZNC-1981-36c-0180_n | | | | Volume
| 36 | |
| 2 | Author
| Michael Entzeroth, Lothar Jaenicke | Requires cookie* | | | Title
| von Blepharisma japonicum Structure-Activity-Relation of Analogues and Homologues of Blepharismone, the Low-M olecular Conjugation Hormone of Blepharisma japonicum | | | | Abstract
| Some functional derivatives o f blepharismone, the low-m olecular conjugation hormone o f Blepharisma japonicum, were synthesised and tested for their biological activity. The lipophilicity constant o f the substituent in 5-position o f the aromatic system directly correlates with the conjugation-inducing effect o f this substance. Any change in the N -form yl-position leads to com pounds less active than blepharismone, non-active or even inhibitory. Blepharismone-related kynurenine derivatives are inhibitors o f the gamone activity depending on structural relationship. | | | |
Reference
| Z. Naturforsch. 37c, 1136—1140 (1982); received August 2/Septem ber 20 1982 | | | |
Published
| 1982 | | | |
Keywords
| Blepharisma japonicu m, Blepharismone, Conjugation, Hormones, Receptors | | | |
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| | | | | TEI-XML for
| default:Reihe_C/37/ZNC-1982-37c-1136.pdf | | | | Identifier
| ZNC-1982-37c-1136 | | | | Volume
| 37 | |
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