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'Bleomycin' in keywords
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1999 (1)
1985 (1)
1Author    Rüdiger Hofm, H. Artm, Ut FollmannRequires cookie*
 Title    Bleom ycin-Iron C om plex and Oxygen Activate Algal R ibonucleotide Reductase  
 Abstract    Ribonucleotide reductase of green algae (Scenedesmus obliquus) is a radical-containing enzyme which rapidly loses activity under anaerobic conditions. Reactivation in the presence of air is enhanced by 10 |j.m iron(II)-bleomycin chelate. The reaction lends new biochemical potential to the antibiotic and should be valuable in mechanistic studies of ribonucleotide reduction. 
  Reference    Z. Naturforsch. 40c, 919—921 (1985); received August 22 1985 
  Published    1985 
  Keywords    Bleomycin, Deoxyribonucleotide Synthesis, Iron, Oxygen Dependence, Ribonucleotide Reduction, Scenedesmus obliquus 
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 TEI-XML for    default:Reihe_C/40/ZNC-1985-40c-0919_n.pdf 
 Identifier    ZNC-1985-40c-0919_n 
 Volume    40 
2Author    Karlheinz Tempel, Hannelore Kortenbeutel, Christina Von ZallingerRequires cookie*
 Title    Bleomycin -Induced DNA Damage and DNA Repair in Chicken Embryo Cells as Compared to X-Irradiation  
 Abstract    Following in vitro-and in ovo-exposure of chicken embryo cells, the level of bleomycin (BM) -induced damage was evaluated by using DNA synthesis, nucleoid sedimentation (SED), and viscometry of alkaline cell lysates (VISC). This damage was compared to X-irradiation, using 5.9-378 nM BM in vitro, 1.5-116 (.ig BM/egg in ovo, and 2-32 Gy, respec­ tively, in vitro as well as in ovo. With respect to BM. the most notable result is the increase in D N A synthesis and VISC at the lowest concentrations of the drug. A decrease in both parameters was observed at high BM concentrations and following exposure to X-rays, con­ comitantly with an increase in SED. Regarding the radiomimetic drug BM and X-rays, dif­ ferent modes of DNA damage and D N A repair are suggested by previous investigations and the present results. Therefore, further evidence is presented, that the chicken embryo can act as a simple, rapid and inexpensive test system to characterize the biological effects of many nucleo-and/or cytotoxic agents. 
  Reference    Z. Naturforsch. 54c, 1068—1074 (1999); received July 14/September 3 1999 
  Published    1999 
  Keywords    Bleomycin, Chicken Embryo, DNA-Damage, DNA-Repair, Nucleoids, X-Irradiation 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-1068.pdf 
 Identifier    ZNC-1999-54c-1068 
 Volume    54