| | 1 | Author
| F. I. Abdel-Hay, M. A. Omara, A. A. El-Barbary, M. El-Badawi | Requires cookie* | | | Title
| Organophosphorus Compounds of Expected Biological Activity, Part II* Preparation of Thiourea Derivatives and N-Aryl-phosphorothiomonoamidates  | | | | Abstract
| The examples of cyclodiphosphazanes so far studied do not contain any nuclei of biological interest [1]. In the present investigation we aimed to introduce ethyl p-amino-benzoate, 2-aminopyridine residues in the phosphazane molecule. For this purpose phos-phorus pentachloride was treated with ethyl p-aminobenzoate, p-anisidine, 2-amino-pyridine and 5-aminoquinoline to give l,3-di-j9-ethoxycarbonylphenyl-, l,3-di-j9-methoxy-phenyl-, l,3-di-2-pyridyl-and l,3-di-5-quinolinyl-2,2,2,4,4,4-hexachlorocyclo-diphos-phazane (la-d), respectively. The compounds la-d were treated with potassium thio-cyanate in acetone. The oily products formed were then treated with p-anisidine, ethyl-p-aminobenzoate and 2-aminopyridine whereupon solid products (2a-h) were obtained. The reaction probably takes place according to the following mechanism [2]. la: b: c: d: Ar 1 Ar C2H5OOCC6H4-(p) CH3OC6H4-(p) C5H4N-(2) C9H6N-(5) Ar Cl /N Cl ci >0< ci SCN NCS 2a: b: c: | | | |
Reference
| Z. Naturforsch. 34b, 297—299 (1979); received October 16 1978 | | | |
Published
| 1979 | | | |
Keywords
| Organophosphorus Compounds, Thiourea Derivatives, Biological Activity | | | |
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| default:Reihe_B/34/ZNB-1979-34b-0297.pdf | | | | Identifier
| ZNB-1979-34b-0297 | | | | Volume
| 34 | |
| 2 | Author
| R. Tacke, M. Strecker, W. S. Sheldrick, E. Heeg, B. Berndt, K. M. Knapstein | Requires cookie* | | | Title
| Sila-Pharmaka, 14. Mitt. [1] Darstellung und Eigenschaften sowie Kristall-und Molekülstruktur von Sila-Difenidol Sila-Drugs, 14 th Communication [1] Preparation and Properties as well as Crystal and Molecular Structure of Sila-Difenidol | | | | Abstract
| Sila-difenidol (6 b), a sila-analogue of the drug difenidol (6 a), was synthesized according to Scheme 1. 6 b and its new precursors 3 and 5 were characterized by their physical and chemical properties, and their structures confirmed by elementary analyses, *H NMR and mass spectroscopy. 6 b crystallizes orthorhombic P 2i 2i 2i with a — 11.523(1), b = 14.366(4), c = 11.450(1) A, Z = 4, Dber = 1.14 gcm-3. The structure was refined to fi = 0.050 for 1897 reflexions. A strong nearly linear intramolecular 0-H---N hydrogen bond of 2.685 A is observed. The anticholinergic, histaminolytic and musculotropic spasmolytic activities of 6 a and 6 b are reported. | | | |
Reference
| Z. Naturforsch. 34b, 1279—1285 (1979); eingegangen am 16. März 1979 | | | |
Published
| 1979 | | | |
Keywords
| Sila-Difenidol, Syntheses, Crystal Structure, Molecular Structure, Biological Activity | | | |
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| default:Reihe_B/34/ZNB-1979-34b-1279.pdf | | | | Identifier
| ZNB-1979-34b-1279 | | | | Volume
| 34 | |
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