Go toArchive
Browse byFacets
Bookbag ( 0 )
'Biological Activities' in keywords Facet   Publication Year 1983  [X]
Results  1 Item
Sorted by   
Section
Publication Year
1983[X]
1Author    Dagmar Denklau, Wolfgang Köhnlein, G. Erd Lüders, Joachim SteilmachRequires cookie*
 Title    Isolation and Fast Purification o f Neocarzinostatin by FPLC-Ion Exchange Chromatography  
 Abstract    Neocarzinostatin, a highly toxic antitum or protein containing an essential nonprotein Chromo­ phore, can be isolated and purified from culture filtrates o f Streptomyces carzinostaticus. Usually a lengthy procedure of up to 60 h is necessary for the isolation, including several chromatographic steps partly under conditions which favour inactivation of the drug by release of chrom ophore. We describe a new method yielding practically clinical grade N eocarzinostatin from crude extracts in 20 min. This very fast and reproducible m ethod was m ade possible by using a Mono Q anion exchange column filled with m onodisperse gel m aterial which has been recently developed. 
  Reference    Z. Naturforsch. 38c, 939 (1983); received July 1/August 31 1983 
  Published    1983 
  Keywords    Zinostatin, Antitumor Antibiotic, Fast Purification, Biological Activity, Protein-H PLC 
  Similar Items    Find
 DEBUG INFO      
 TEI-XML for    default:Reihe_C/38/ZNC-1983-38c-0939.pdf 
 Identifier    ZNC-1983-38c-0939 
 Volume    38