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'Bilayer' in keywords Facet   Publication Year 1988  [X]
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1Author    M. Suwalsky, L. Gimenez, V. Saenger, F. NeiraRequires cookie*
 Title    X-Ray Studies on Phospholipid Bilayers. VIII. Interactions with Chlorpromazine * HCl  
 Abstract    Chlorpromazine is a widely used phenothiazine tranquilizer known to alter the shape of normal erythrocytes and their osmotic fragility. In order to understand the nature of the interactions chlorpromazine • HCl (CPZ HCl) was made to interact with phospholipid bilayers formed by dimyristoylphosphatidylethanolamine (DMPE) and dimyristoylphosphatidylcholine (DMPC). This study was carried out by X-ray diffraction on crystalline powders of various molar mixtures of CPZ -HCl with DMPE and DMPC, with and without water. It was found that CPZ -HCl significa-tively affects the bilayer structure of DMPC in the presence of water, but not that of DMPE. 
  Reference    Z. Naturforsch. 43c, 742—748 (1988); received March 23/June 13 1988 
  Published    1988 
  Keywords    X-Ray Diffraction, Phospholipid, Bilayer, Chlorpromazine @BULLET HCl 
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 TEI-XML for    default:Reihe_C/43/ZNC-1988-43c-0742.pdf 
 Identifier    ZNC-1988-43c-0742 
 Volume    43