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1995 (1)
1Author    C.La Casa, M.J Martin Calero, C. Alarcon De La Lastra, V. Motilva, M. J. Ayuso, C., Martin Cordero, A. Lopez VergaraRequires cookie*
 Title    Role of Mucus Secretion and Sulfhydryl Groups in Gastroprotection Mediated by a Flavonoid Fraction of Bidens aurea  
 Abstract    The aerial parts of Bidens aurea (Aiton) Sherff have been used in folk medicine as an antiulcer agent. The efficacy of an ether extract to prevent gastric mucosal damage produced by several necrotic agents was studied in rats. The best efficiency was against lesions induced by 30% NaCl with a significant decrease of damage at all doses tested (250, 125 and 62.5 mg kg'1). In contrast, only the highest dose (250 mg kg"1) was effective on gastric erosions in­ duced by 0.6 n HC1. This effect could not be related with the mucus gel production only since the groups treated with of absolute ethanol or 30% NaCl before and then received 250 mg kg"1 of the ether extract increased significantly the am ount of gastric mucus and its glycoprotein content. However, the ether extract of Bidens aurea enhanced the production of mucosal non-protein SH groups at all doses assayed after treatm ent with absolute ethanol and 0.6 n HC1. With NaCl-induced gastric injury, also the highest dose (250 mg k g 1) pro­ duced an increase of this param eter. The results suggest that a slight augmentation of the mucus gel concentration and the increase of non-protein sulfhydryl compounds, could con­ tribute to the functional protection mechanism mediated by a flavonoid fraction of B.aurea in these experimental models. 
  Reference    Z. Naturforsch. 50c, 854—861 (1995); received June 1/August 15 1995 
  Published    1995 
  Keywords    Cytoprotection, Bidens aurea, Sulfhydryl Groups, Aurones, Chalcones 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0854.pdf 
 Identifier    ZNC-1995-50c-0854 
 Volume    50 
2Author    M.J M Artín Calero, C.La Casa, V. Motilva, A. L. Ópez, C. Alarcó, La De, LastraRequires cookie*
 Title    Healing Process Induced by a Flavonic Fraction of Bidens aurea on Chronic Gastric Lesion in Rat. Role of Angiogenesis and Neutrophil Inhibition  
 Abstract    The aim of this study was to elucidate the mechanism of the healing process mediated by the flavonic fraction of Bidens aurea on chronic gastric ulceration induced by 5% acetic acid in rats. The diethyl ether extract (125 and 62.5 mg kg-1 body weight) was administered in a single doses, 7 and 14 days after provocation of lesions. O ur results demonstrated that both doses significantly decreased the macro and microscopic ulcer index. Usually after 14-days treatment the lesions were found completely covered with regenerative epithelium and also an important proliferation of blood vessels was observed. Myeloperoxidase (M P O) activity was assayed and used as an index of leucocyte infiltration. Application of acetic acid pro­ duced a significant increase of this activity 7 days after induction of chronic injury. A d m in ­ istration of 125 mg kg 1 of the ether extract provoked a sharp reduction on the enzymatic activity at the same period. After 14 days, this decrease was higher with both doses (p<0.001). In addition, the macroscopic examination showed a drastic reduction of leucocyte infiltration in treated groups. These results suggest that the recovery of vascularization of the ulcerated area and the decrease of neutrophil infiltration are involved in the antiulcerogenic effect of the flavonoid fraction of Bidens aurea. 
  Reference    Z. Naturforsch. 51c, 570—577 (1996); received March 11/May 21 1996 
  Published    1996 
  Keywords    Bidens aurea, Flavonoids Chronic Gastric Ulcer, Neutrophils, Myeloperoxidase Activity 
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 TEI-XML for    default:Reihe_C/51/ZNC-1996-51c-0570.pdf 
 Identifier    ZNC-1996-51c-0570 
 Volume    51