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1996 (1)
1Author    Martin Semara, HeidrunA. Nke3, Wolf-Rüdiger Arendholzb, Robert Veiten0, Wolfgang Steglich0Requires cookie*
 Title    Lachnellins A, B, C, D, and Naphthalene-l,3,8-triol, Biologically Active Compounds from a Lachnellula Species (Ascomycetes)  
 Abstract    In the course of our search for new biologically active metabolites, lachnellin A (1), a metabolite with high cytotoxic and antimicrobial activities, the structurally related lachnellins B. C and D (3, 4, 7), and naphthalene-l,3,8-triol (8), an inhibitor of malate synthase (EC 4.1.3.2), were isolated from submerged cultures o f the ascomycete Lachnellula sp. A 3 2 -8 9 . The antimicrobial, cytotoxic and phytotoxic activities of lachnellin A depended on its reactiv­ ity and could be abolished by the addition of cysteine. The enzyme inhibiting activity of (8) was due to reactive intermediates during melanization and was no longer observed in the presence of serum albumin. In addition, rac-scytalone (9), (+)-fra/7s-3,4-dihydro-3,4,8-trihy-droxy-l(2//)-naphtha!enone (10). 2,5-dihydroxytoluene (11), and (/?)-(-)-5-methylmellein (12) were obtained from the same source and biologically characterized. 
  Reference    Z. Naturforsch. 51c, 500 (1996); received March 1/April 29 1996 
  Published    1996 
  Keywords    Lachnellin A, B, C D Glyoxylate Cycle, N aphthalene-1, 3, 8-triol, Malate Synthase, Melanization, Lachnellula sp 
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 TEI-XML for    default:Reihe_C/51/ZNC-1996-51c-0500.pdf 
 Identifier    ZNC-1996-51c-0500 
 Volume    51