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1985 (1)
1Author    Franz Dallacker, Thomas Böhmel, W. Ilhelm Müllners, HeinrichM. ÜckterRequires cookie*
 Title    Amin-carbamoyl-10B-boran, Darstellung und biologische Eigenschaften Amine-carbamoyl-dihydro-10B-borane, Preparation, and Biological Properties  
 Abstract    The chemical section deals with the synthesis of sodiumcyano-"'B-borhydride (3) from l0B-boric acid trimethyl ester (1) via sodium-inB-borhydride (2). By converting 3 with trimethylammonium chloride, trimethylamine-cyano-10B-borane (4) is formed which, via nitrilium tetrafluoroborate 5, is transformed by water to Trimethylamine-carboxy-dihydro-luB-borane (6). Trimethylamine-ethoxycarbonyl-dihydro-l()B-borane (8b) and amine-carbamoyl-dihydro-"'B-borane (8c) can be synthesized from the imidazolid 8a. In the biological section an orientation to the toxicity and the tumor affinity of the compounds 6, 7. and 8c are described. Further the possibility is shown by achieving a maximal concentration of 10B-boron in the tumor whilst at the same time retaining as low a concentration of 1()B-Boron as possible in the surrounding tissue. 
  Reference    Z. Naturforsch. 40c, 344 (1985); received March 4/April 12 1985 
  Published    1985 
  Keywords    1(, B-Boron, Neutron Capture Therapy, Amine-carboxy-dihydro-'°B-borane 
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 TEI-XML for    default:Reihe_C/40/ZNC-1985-40c-0344.pdf 
 Identifier    ZNC-1985-40c-0344 
 Volume    40