| | 1 | Author
| Dorothee Petz, H. Ans-G, Erhard Löffler, Friedh Schneider | Requires cookie* | | | Title
| Inhibition of E. coli l -Asparaginase by Reaction with 2,3-Butanedione. Chemical Modification of Arginine and Histidine Residues  | | | | Abstract
| The inactivation o f E. coli asparaginase by 2,3-butanedione studied with L-asparagine and dia-zooxonorvaline as substrates obeys pseudo first order kinetics. Activity losses are linear with re spect to arginine and histidine m odification, with com plete inactivation being correlated with alter ation o f one arginine and one histidine per subunit. The rate o f inactivation o f the enzym was re duced in the presence o f com petitive inhibitors like L-2-am ino-2-carboxyethane-sulfonam ide. U n der comparable conditions 1,2-cyclo hexanedione does not affect the activity o f L-asparaginase. | | | |
Reference
| Z. Naturforsch. 34c, 742 (1979); received May 8 1979 | | | |
Published
| 1979 | | | |
Keywords
| Asparaginase, 2, 3-Butanedione, Arginine and Histidine Residues | | | |
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| default:Reihe_C/34/ZNC-1979-34c-0742.pdf | | | | Identifier
| ZNC-1979-34c-0742 | | | | Volume
| 34 | |
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