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1997 (1)
1979 (1)
1Author    Petra Köpf-Maier, Hartmut KöpfRequires cookie*
 Title    Vanadocen-dichlorid - ein weiteres Antitumor-Agens aus der Metallocenreihe Vanadocene Dichloride -Another Antitumor Agent from the Metallocene Series  
 Abstract    The antitumor activity of vanadocene dichloride is investigated against Ehrlich ascites tumor in CFi mice. The application of 80 or 90 mg/kg 24 h after transplantation achieves 100% tumor inhibition until day 30. On treatment with higher doses death of an increasing number of animals is caused by substance toxicity. The results of this study indicate that vanadocene dichloride exhibits antineoplastic properties similar to those found for titanocene dichloride and cis-dichlorodiammine-platinum(II). 
  Reference    Z. Naturforsch. 34b, 805—807 (1979); eingegangen am 15. März 1979 
  Published    1979 
  Keywords    Vanadocene Dichloride, Metallocenes, Antitumor Activity, Ehrlich Ascites Tumor 
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 TEI-XML for    default:Reihe_B/34/ZNB-1979-34b-0805.pdf 
 Identifier    ZNB-1979-34b-0805 
 Volume    34 
2Author    DanielN. Kushev, NadejdaC. Spassovska, SvetoslavI. Taxirov, KonstantinC. GrancharovRequires cookie*
 Title    Cytotoxicity and Antitumor Activity of Platinum(II) Complexes of Aromatic and Cycloalkanecarboxylic Acid Hydrazides  
 Abstract    N ew platinum(II) complexes of cyclohexanecarboxylic acid hydrazide (chcah) were synthe­ sized and characterized by elem ental analysis, IR. and 'H NM R spectra. Their inhibitory effects on cell growth and macromolecular synthesis o f Friend leukem ia cells in culture as well as the in vivo antitumor activity towards L1210 leukemia in mice were compared with those of complexes containing differently substituted aromatic acid hydrazides. Some of the complexes exhibited antineoplastic activity. N o correlation betw een the in vitro cytotoxicity and the in vivo antitumor activity was found. H owever, there was a relationship between the in vitro macromolecular synthesis inhibition profile and the in vivo antineoplastic effect, similar to that of cisplatin. On the other hand, only agents containing one ammine ligand were active in vivo. The substitution o f the aromatic ring by a cycloalkane residue increased significantly the antitumor effect, with [Pt(NH3)(chcah)Cl2] being the most active compound in this study. 
  Reference    Z. Naturforsch. 52c, 49 (1997); received August 1/September 18 1996 
  Published    1997 
  Keywords    Platinum(II) Complexes, Cytotoxicity, Antitumor Activity, Macromolecular Synthesis Inhibition 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0049.pdf 
 Identifier    ZNC-1997-52c-0049 
 Volume    52