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'Antimuscarinic and Papaverine Like Activity' in keywords
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1983 (1)
1Author    Reinhold Tacke, Hartwig Lange, WilliamS. Sheldrick, Günter Lambrecht, Ulrich Moser, Ernst MutschierRequires cookie*
 Title    Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon Sila-Pharmaca, 31 th Communication [1J Synthesis, Structure, and Pharmacological Properties of Diphenyl(2-piperidinoethoxymethyl)silanol and its Carbon Analogue  
 Abstract    In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong 0-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4 a and 4 b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ^4b). 
  Reference    Z. Naturforsch. 38b, 738—746 (1983); eingegangen am 5. Januar 1983 
  Published    1983 
  Keywords    Sila-Substitution, Crystal and Molecular Structure, Antimuscarinic and Papaverine-Like Activity 
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 TEI-XML for    default:Reihe_B/38/ZNB-1983-38b-0738.pdf 
 Identifier    ZNB-1983-38b-0738 
 Volume    38