Go toArchive
Browse byFacets
Bookbag ( 0 )
'Antiherpes Activity' in keywords
Results  1 Item
Sorted by   
Section
Publication Year
1999 (1)
1Author    IvankaG. Stankova3, M. Ario, F. Simeonovb, Vera Maximova0, AngelS. Galabov0, EvgenyV. GolovinskydRequires cookie*
 Title    Synthesis and Anti-Virus Activity of Some Nucleosides Analogues  
 Abstract    New 3'-, 5'-, 5-bromo-2'-deoxyuridine (3 a -g) and 3'-, 5'-thymidine (4 a -i) analogues with amino acid and peptide residues were synthesized and evaluated for antiviral activity. The influence of long peptide chains, essential amino acids and the effect of this structural modifi­ cation on the antiviral activity has been also reported. Three 5-bromo-2'-deoxyuridine derivatives containing glycyl-, glycyl-glycyl-and glycyl-gly-cyl-glycyl-residues (3a, 3b, 3c) showed a strong activity against the herpes virus PsRV and a moderate one vs. HSV-1. The corresponding thymidine analogues were considerably less effective, and only com­ pounds 4d and 4h showed a borderline effect against PsRV. 
  Reference    Z. Naturforsch. 54c, 75—83 (1999); received August lO/October 20 1998 
  Published    1999 
  Keywords    5-Bromo-2'-Deoxyuridine, Thymidine, Amino Acids, Peptides, Antiherpes Activity 
  Similar Items    Find
 DEBUG INFO      
 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0075.pdf 
 Identifier    ZNC-1999-54c-0075 
 Volume    54