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1982 (1)
1981 (1)
1Author    TimM. Anke, Bruno-MaxG. Iannetti, Wolfgang SteglichRequires cookie*
 Title    Antibiotika aus Basidiomyceten, XV [1]. l-Hydroxy-2-nonin-4  
 Abstract    on, ein antifungischer und cytotoxischer Metabolit aus Ischnoderma benzoinum (Wahl.) Karst. Antibiotics from Basidiomycetes. XV [1]. l-Hydroxy-2-nonyn-4-one, an Antifungal and Cytotoxic M etabolite from Ischnoderma benzoinum (W ahl.) Karst. A new antibiotic, 1-hydroxy-2-nonyn-4-one (1), has been isolated from submerged cultures of several strains of Ischnoderma benzoinum. The compound exhibits high inhibitory activity against yeasts and filamentous fungi at concentrations o f 1 -5 ng/ml. D N A , RNA, and protein syntheses in cells of the ascitic form o f Ehrlich carcinoma are strongly inhibited by the same concentrations. 
  Reference    Z. Naturforsch. 37c, 1—4 (1982); received October 31 1981 
  Published    1982 
  Keywords    Acetylenic Metabolite, Antifungal, Cytotoxic 
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 TEI-XML for    default:Reihe_C/37/ZNC-1982-37c-0001.pdf 
 Identifier    ZNC-1982-37c-0001 
 Volume    37 
2Author    D. Ieter Berg, W. Ilfried, D. Raber, Bayer Ag, Agrochemical Division, Wuppertal, Bundesrepublik Deutschland, Hasso Von Hugo, W. Erner, HumM. El, D. Ieter MayerRequires cookie*
 Title    The Effect of Clotrimazole and Triadimefon on 3-Hydroxy-3-Methyl-Glutary 1-Co A-Reductase-[EC Activity in Saccharomyces cerevisiae  
 Abstract    Clotrimazole and triadimefon are known as potent inhibitors of ergosterol synthesis in pathogenic yeasts and fungi, respectively. As their mode of action generally the inhibition of sterol desmethylation reactions is accepted. We report about a second effect, a "feed-back" inhibition of 3-hydroxy-3-methyl-glutaryl (HMG)-CoA-reductase by accumulation of ergosterol precursors. Addition of lanosterol to intact cells leads to an inhibition of HMG-CoA-reductase as well, but not to fungistatic effects. From the reported data the influences of clotrimazole and triadimefon have to be considered as an inhibition of desmethylation reactions involved in ergosterol synthesis of yeasts and fungi with a concomitant decreased production of mevalonate. 
  Reference    Z. Naturforsch. 36c, 798—803 (1981); received July 17 1981 
  Published    1981 
  Keywords    CoA-Reductase, Sterol Biosynthesis, Antifungals, Antimycotics, Mode of Action 
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 TEI-XML for    default:Reihe_C/36/ZNC-1981-36c-0798.pdf 
 Identifier    ZNC-1981-36c-0798 
 Volume    36