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'Antifungal' in keywords Facet   section ZfN Section C:Volume 036  [X]
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1981 (1)
1Author    D. Ieter Berg, W. Ilfried, D. Raber, Bayer Ag, Agrochemical Division, Wuppertal, Bundesrepublik Deutschland, Hasso Von Hugo, W. Erner, HumM. El, D. Ieter MayerRequires cookie*
 Title    The Effect of Clotrimazole and Triadimefon on 3-Hydroxy-3-Methyl-Glutary 1-Co A-Reductase-[EC 1.1.1.341- Activity in Saccharomyces cerevisiae  
 Abstract    Clotrimazole and triadimefon are known as potent inhibitors of ergosterol synthesis in pathogenic yeasts and fungi, respectively. As their mode of action generally the inhibition of sterol desmethylation reactions is accepted. We report about a second effect, a "feed-back" inhibition of 3-hydroxy-3-methyl-glutaryl (HMG)-CoA-reductase by accumulation of ergosterol precursors. Addition of lanosterol to intact cells leads to an inhibition of HMG-CoA-reductase as well, but not to fungistatic effects. From the reported data the influences of clotrimazole and triadimefon have to be considered as an inhibition of desmethylation reactions involved in ergosterol synthesis of yeasts and fungi with a concomitant decreased production of mevalonate. 
  Reference    Z. Naturforsch. 36c, 798—803 (1981); received July 17 1981 
  Published    1981 
  Keywords    CoA-Reductase, Sterol Biosynthesis, Antifungals, Antimycotics, Mode of Action 
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 TEI-XML for    default:Reihe_C/36/ZNC-1981-36c-0798.pdf 
 Identifier    ZNC-1981-36c-0798 
 Volume    36