| | 1 | Author
| Lackner | Requires cookie* | | | Title
| Octacidomycine, IV : Neue Totalsynthese von rac-Octacidomycin und strukturverwandten Oligocarbonsäuren Octacidom ycins, I V : A New Total Synthesis of rac-O ctacidom ycin and Structurally R elated O ligocarboxylic A cids A ndreas K rause, H elm ut  | | | | Abstract
| a new strategy, an improved total synthesis of the unique antibiotic octacidomy-cin (1) and of structurally related oligocarboxylic acids was developed (Scheme 1,2). Starting from 3 and the tetraethylester of l,17-dibromo-6,6,12,12-heptadecane-tetracarboxylic acid (6) as a key compound, systematical fragment condensations lead to the nonatriacontane-pentadecacarboxylic acid 11 and hence to the 1,3,9,15,21,27,33,39-nonatriacontane-octacarbo-xylic acid 1. The synthetic pathway can easily be modified and generally be applied for the synthesis of a broad variety of hitherto unknown oligocarboxylic acids or their esters, respec tively, and even of cyclic analogues (Scheme 2). | | | |
Reference
| Z. Naturforsch. 53b, 1043—1050 (1998); eingegangen am 22. Juni 1998 | | | |
Published
| 1998 | | | |
Keywords
| Antibiotics, Octacidomycins, Oligocarboxylic Acids, Synthesis, NMR Data Following | | | |
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| default:Reihe_B/53/ZNB-1998-53b-1043.pdf | | | | Identifier
| ZNB-1998-53b-1043 | | | | Volume
| 53 | |
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