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'Antibiotic' in keywords Facet   Publication Year 1995  [X]
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1995[X]
1Author    Brigitte Simona, Timm Anke3, U. Andersb, M. Neuhausb, F. HansskebRequires cookie*
 Title    Collybial, a New Antibiotic Sesquiterpenoid from Collybia confluens (Basidiomycetes)  
 Abstract    A new antibiotic was isolated from fermentations of an american strain of Collybia con­ fluens. Its structure was elucidated by spectroscopic methods as 2,10,10-trim ethal-4-oxo-tri-cyclo[7.2.0.025]undec-6-en-carbaldehyde (with the relative stereo chemistry IS, 2 R. 5 R. 9 R) (1). The inhibitor, which was named collybial, is structurally related to koraiol, a sesquiter­ penoid isolated from Pinus koraiensis (Khan V. A . (1979), Khim. Prir. Soedin 5, 6 5 2 -6 5 8). Collybial inhibited the growth of Gram-positive bacteria at concentrations starting from 21.5 | i m . The propagation of vesicular stomatitis virus (V SV) in baby hamster kidney (B H K -21) cells was inhibited by 21.5 [.i m collybial. Cytotoxic effects on B H K cells were observed at 5 fold higher concentrations. 
  Reference    Z. Naturforsch. 50c, 173 (1995); received O ctober 12/Novem ber 11 1994 
  Published    1995 
  Keywords    Collybia confluens, Basidiomycetes, Antibiotic, Antiviral, Cytotoxic Activity 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0173.pdf 
 Identifier    ZNC-1995-50c-0173 
 Volume    50 
2Author    Kirsten Lorenzena, TimmA. Nkea, Silvia Konetschny-Rappb, Werner ScheuerbRequires cookie*
 Title    5-Hydroxy-3-vinyl-2(5H)-furanone -a New Inhibitor of Human Synovial Phospholipase A 2 and Platelet Aggregation from Fermentations of a C alyptella Species (Basidiomycetes)  
 Abstract    5-Hydroxy-3-vinyl-2(5H)-furanone, a potent and selective inhibitor of human synovial phospholipase A 2 was isolated from fermentations of a Calyptella species. Its structure as identified by spectroscopic methods is identical to PA 147, an antibiotic previously isolated from a streptomycete. 5-hydroxy-3-vinyl-2(5H)-furanone inhibits the aggregation of human and bovine platelets stimulated by different inducers and exhibits weak antimicrobial activities. 
  Reference    Z. Naturforsch. 50c, 403—409 (1995); received January 16/February 10 1995 
  Published    1995 
  Keywords    Basidiomycetes, Calyptella Species, Platelet Aggregation, Antibiotics, Phospholipase A 2 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0403.pdf 
 Identifier    ZNC-1995-50c-0403 
 Volume    50