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1Author    K. EiseleRequires cookie*
 Title    Sequence Variation on an Antibiotically Active Tripeptide Seven tripeptides with the sequence L-Arg-D,L-X-L-Phe were synthesised. Three of these peptides showed anti- biotical activity on fungi. The amino-and the carboxylic terminus of the peptide L-Arg-D,L-Phe-L-Phe, which showed antibiotical activity, were changed to give the sequences L-X-D,L-Phe-L-Phe or L-Arg-D,L-Phe-L-X respectively  
 Abstract    The resulting tripeptides showed no antibiotical activity. 
  Reference    (Z. Naturforsch. 30c, 541 [1975]; eingegangen am 11. Februar/3. April 1975) 
  Published    1975 
  Keywords    Antibiotics, Sequence Variation, Peptide Synthesis 
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 TEI-XML for    default:Reihe_C/30/ZNC-1975-30c-0541_n.pdf 
 Identifier    ZNC-1975-30c-0541_n 
 Volume    30 
2Author    R. Kanne, H. ZähnerRequires cookie*
 Title    Concentrations of W ild -T y p e and a Macrotetrolide Negative Mutant of Streptomyces griseus  
 Abstract    The studied macrotetrolide negative mutant of Streptomyces griseus showed a different spe­ cificity of potassium accumulation than the macrotetrolide producing wild-type, indicating, that the macrotetrolides may be part of the physiological potassium carrier. 
  Reference    (Z. Naturforsch. 31c, 115 [1976]; received November 3 1975) 
  Published    1976 
  Keywords    Potassium Sodium, Ionophores, Antibiotics, Transport 
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 TEI-XML for    default:Reihe_C/31/ZNC-1976-31c-0115.pdf 
 Identifier    ZNC-1976-31c-0115 
 Volume    31 
3Author    Anna Aiello, Ernesto Fattorusso, M. Arialuisa, M. EnnaRequires cookie*
 Title    A New Antibiotic Chloro-Sesquiterpene from the Caribbean Sponge Smenospongia aurea  
 Abstract    A new sesquiterpene phenol, containing the rather uncommon chlorine atom, was isolated from a sample of Smenospongia aurea collected along Baham a's Islands. Its structure has been elucidated by spectroscopic analysis and confirmed via synthesis. This com pound exhibited antibacterial activity. 
  Reference    Z. Naturforsch. 48b, 209—212 (1993); received September 18. 1992 
  Published    1993 
  Keywords    Spongidae, Smenospongia aurea, Sesquiterpene, Antibiotic, N M R Spectra 
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 TEI-XML for    default:Reihe_B/48/ZNB-1993-48b-0209.pdf 
 Identifier    ZNB-1993-48b-0209 
 Volume    48 
4Author    JohannK. Lessmann, Helmut Rupa, Lackner, Karen Schmidt-Bäse, GeorgeM. SheldrickRequires cookie*
 Title    Holger  
 Abstract    The isolation o f Juglorubin (2) from cultures o f Streptomyces spp., which produce a series o f other hydroxynaphthoquinones, is described. 2 is a unique, unusually condensed ionic color­ 
  Reference    Z. Naturforsch. 48b, 672 (1993); eingegangen am 21. Dezember 1992 
  Published    1993 
  Keywords    Antibiotics, Juglomycins, X -Ray, N M R Spectra 
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 TEI-XML for    default:Reihe_B/48/ZNB-1993-48b-0672.pdf 
 Identifier    ZNB-1993-48b-0672 
 Volume    48 
5Author    LacknerRequires cookie*
 Title    Octacidomycine, IV : Neue Totalsynthese von rac-Octacidomycin und strukturverwandten Oligocarbonsäuren Octacidom ycins, I V : A New Total Synthesis of rac-O ctacidom ycin and Structurally R elated O ligocarboxylic A cids A ndreas K rause, H elm ut  
 Abstract    a new strategy, an improved total synthesis of the unique antibiotic octacidomy-cin (1) and of structurally related oligocarboxylic acids was developed (Scheme 1,2). Starting from 3 and the tetraethylester of l,17-dibromo-6,6,12,12-heptadecane-tetracarboxylic acid (6) as a key compound, systematical fragment condensations lead to the nonatriacontane-pentadecacarboxylic acid 11 and hence to the 1,3,9,15,21,27,33,39-nonatriacontane-octacarbo-xylic acid 1. The synthetic pathway can easily be modified and generally be applied for the synthesis of a broad variety of hitherto unknown oligocarboxylic acids or their esters, respec­ tively, and even of cyclic analogues (Scheme 2). 
  Reference    Z. Naturforsch. 53b, 1043—1050 (1998); eingegangen am 22. Juni 1998 
  Published    1998 
  Keywords    Antibiotics, Octacidomycins, Oligocarboxylic Acids, Synthesis, NMR Data Following 
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 TEI-XML for    default:Reihe_B/53/ZNB-1998-53b-1043.pdf 
 Identifier    ZNB-1998-53b-1043 
 Volume    53 
6Author    Axel Lifferth3, IsabelB. Ahnera, Ut Helm, Lackner, M. Artina SchäferbRequires cookie*
 Title    Synthese und Struktur von Prolinring-modifizierten Actinomycinen des X-Typs Synthesis and Structure of Proline Ring Modified Actinomycins of the X-Type  
 Abstract    The first total synthesis o f actinomycins containing L-4-hydroxyproline (1) and the separa­ tion and NM R spectroscopic assignment o f the regioisomers X (V* and iso-X0/i (lc, le) are described. The synthetic X 0/j proves, that the oxidized proline ring of the natural actinomycins 
  Reference    Z. Naturforsch. 54b, 681—6 (1999); eingegangen am 15. Januar 1999 
  Published    1999 
  Keywords    Antibiotics, Actinomycins, Synthesis, Crystal Structure, NM R Data 
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 TEI-XML for    default:Reihe_B/54/ZNB-1999-54b-0681.pdf 
 Identifier    ZNB-1999-54b-0681 
 Volume    54 
7Author    Bernd Schulz-Harder, Ernst-Randolf LochmannRequires cookie*
 Title    Initiation in einem Polyribosomen-abhängigen Protein-synthetisierenden zellfreien System aus Saccharomyces Initiation in a Polyribosome-Dependent Protein-Synthesizing Cell-Free System from Saccharomyces  
 Abstract    A method to prepare polyribosomes from yeasts by using the french-press is described. The highest yield of polyribosomes was derived from late log-phase cells. These polyribosomes, in­ cubated in a cell-free system, were able to reinitiate protein synthesis, which was shown by in­ hibiting aminoacid incorporation by aurintricarboxylic acid, edeine and sodiumfluoride. W e de­ veloped the translational system in order to look for the optimal ion-conditions of a DNA-dependent protein-synthesizing system. W e found out that at the optimal MgCL-concentration (6 mM) protein synthesis was strongly inhibited by Mangan ions which are required for transcription in yeast. If protein-synthesis was carried out with 2 mM and 3 mM M gCU maximal aminoacid incorporation was observed at 2 mM and 1.5 mM M nCl2 . 
  Reference    (Z. Naturforsch. 31c, 169 [1976]; eingegangen am 10. November 1975) 
  Published    1976 
  Keywords    Yeast, Polyribosomes, Cell-Free Protein Synthesis, Antibiotics, Ion-Conditions 
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 TEI-XML for    default:Reihe_C/31/ZNC-1976-31c-0169.pdf 
 Identifier    ZNC-1976-31c-0169 
 Volume    31 
8Author    R. Einhard KanneRequires cookie*
 Title    Isolation and Characterization of a Potassium Specific Ionophore from Streptococcus fuecalis  
 Abstract    The synthesis of a potassium and rubidium specific ionophore by S treptococcu s faecalis has been proved, using bilayer measurements. The characteristics of this substance agree with the ones, published for free mobile carriers, such as valinomycin and the macrotetrolides. 
  Reference    (Z. Naturforsch. 32c, 926 [1977]; received August 24 1977) 
  Published    1977 
  Keywords    Potassium, Ionophores, Transport, Antibiotics, Black Lipid Membranes 
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 TEI-XML for    default:Reihe_C/32/ZNC-1977-32c-0926.pdf 
 Identifier    ZNC-1977-32c-0926 
 Volume    32 
9Author    Ute Laudenbach, Jürgen KesselmeierRequires cookie*
 Title    Some Observations on the Saponin Accumulation in Oat Seedlings and on the Transformation of the Avenacosides to the Antibiotic 26-Desgluco-avenacosides  
 Abstract    The accumulation o f the steroidal saponins avenacoside A and B in oat was investigated in green and etiolated seedlings and was found to be strictly bound to the growth o f the seedlings. N o significant differences were detected between green and etiolated seedlings, showing that there is no relation between saponin accumulation and plastid developm ent. As the role o f the oat saponins has to be seen as a protective device against fungi and bacteria, the transformation o f the inactive avenacosides to their corresponding antibiotic 26-desgluco-avenacosides was tested in dependence o f pH and temperature. During disruption o f leaves, transformation occurs almost com pletely over a wide pH-range (pH 4 —pH 10); the degree o f transformation exhibits no distinct temperature optimum but a drastic decrease at 70 °C. 
  Reference    Z. Naturforsch. 37c, 1095 (1982); received July 10 1982 
  Published    1982 
  Keywords    Saponin Accumulation, Antibiotic, /?-Glucosidase, Oat 
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 TEI-XML for    default:Reihe_C/37/ZNC-1982-37c-1095.pdf 
 Identifier    ZNC-1982-37c-1095 
 Volume    37 
10Author    A. Stärk, T. Anke, A. Kirfel, G. WillRequires cookie*
 Title    Lentinellic Acid, a Biologically Active Protoilludane Derivative from Lentinellus Species (Basidiomycetes) [1]  
 Abstract    A new antimicrobial and cytotoxic sesquiterpenoid, lentinellic acid (1), has been isolated from submerged cultures of Lentinellus ursinus and L. omphalodes. The structure of the antibiotic was elucidated by spectroscopic methods and a single crystal X-ray analysis. 1 may be formed biogenetically by condensation of a protoilludane aldehyde 4 with a malonate unit. 
  Reference    Z. Naturforsch. 43c, 177—183 (1988); received October 16 1987 
  Published    1988 
  Keywords    Lentinellus, Basidiomycetes, Sesquiterpenoids, Protoilludanes, Lentinellic Acid, Antibiotics 
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 TEI-XML for    default:Reihe_C/43/ZNC-1988-43c-0177.pdf 
 Identifier    ZNC-1988-43c-0177 
 Volume    43 
11Author    Andreas Stärk, Timm Anke, Ursula Mocek, Wolfgang SteglichRequires cookie*
 Title    Omphalone, an Antibiotically Active Benzoquinone Derivative from Fermentations of Lentinellus omphalodes [1]  
 Abstract    Om phalone, a new antibiotic, cytotoxic, and phytotoxic pigment has been isolated from fer­ mentations o f a Canadian strain of Lentinellus omphalodes. Its structure has been established as 2-(4-methylfuran-2-yl)-l,4-benzoquinone (1) by spectroscopic investigations and conver­ sion into leuco-acetate 2. 
  Reference    Z. Naturforsch. 46c, 989—992 (1991); received February 6/July 20 1991 
  Published    1991 
  Keywords    Om phalone, Benzoquinone Derivative, Antibiotic, Lentinellus omphalodes, Basidiomycete 
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 TEI-XML for    default:Reihe_C/46/ZNC-1991-46c-0989.pdf 
 Identifier    ZNC-1991-46c-0989 
 Volume    46 
12Author    JoH. An, N. Es, D. Asen, Ro Ck, W. Olfgang SteglichRequires cookie*
 Title    Phellodonic Acid, a New Biologically Active Hirsutane Derivative from Phellodon melaleucus (Thelephoraceae, Basidiomycetes) [1]  
 Abstract    A new hirsutane derivative, phellodonic acid (1), has been isolated from fermentations of Phellodon melaleucus strain 87113. Its structure was elucidated by spectroscopic methods. The compound exhibits antibiotic activities towards bacteria and fungi. 1 is the first bioactive metabolite from cultures of a species belonging to the family Thelephoraceae. 
  Reference    Z. Naturforsch. 48c, 545—549 (1993); received April 23 1993 
  Published    1993 
  Keywords    Phellodon melaleucus, Sesquiterpenoids, Hirsutane, Phellodonic Acid, Antibiotic 
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 TEI-XML for    default:Reihe_C/48/ZNC-1993-48c-0545.pdf 
 Identifier    ZNC-1993-48c-0545 
 Volume    48 
13Author    Kirsten Lorenzen, Timm Anke, Uwe Anders, H. Erm An Hindermayr, Fritz HansskeRequires cookie*
 Title    Two Inhibitors of Platelet Aggregation from a Panus Species (Basidiomycetes)  
 Abstract    Two inhibitors of platelet aggregation were isolated from fermentations of Panus sp. 9096. One inhibitor proved to be identical to naematolon (2), an antibiotic previously isolated by S. Backens et al. from several Hypholoma species. The other metabolite, panudial (1), is a new nordrimane (cw-annelation of the bicyclus) lacking the carbon atom in position 10 of the drimane skeleton. Panudial is a potent inhibitor of bovine and human platelet aggregation stimulated by different inducers. 
  Reference    Z. Naturforsch. 49c, 132—138 (1994); received September 1/ 
  Published    1994 
  Keywords    Basidiomycetes, Lentineae, Panus Species, Platelet Aggregation, Antibiotics, Drimanes 
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 TEI-XML for    default:Reihe_C/49/ZNC-1994-49c-0132.pdf 
 Identifier    ZNC-1994-49c-0132 
 Volume    49 
14Author    K. Irsten Lorenzen, Tim, H. Erm, H. Inderm Ayr, F. Ritz HansskeRequires cookie*
 Title    4-Epidihydrocochlioquinone B and 14-Epicochlioqumone B, Antibiotics from Fermentations of the Ascomycete Neobulgaria pur a: Structure Elucidation and Effects on Platelet Aggregation  
 Abstract    14-Epicochlioquinone B (1) and 14-epidihydrocochlioquinone B (2) were isolated from sub­ merged cultures of Neobulgaria pura (Pers. ex Fr.) Petrak. 14-Epicochlioquinone B is a potent inhibitor of hum an and bovine platelet aggregation stimulated by different inducers. 14-Epidihydrocochlioquinone B does not inhibit the aggregation of platelets. In addition, both 1 and 2 exhibited cytotoxic and antimicrobial activites. 
  Reference    Z. Naturforsch. 49c, 312—320 (1994); received September 9 1993/ 
  Published    1994 
  Keywords    Ascomycetes, Helotiales, Platelet Aggregation, Antibiotics, Cochlioquinones 
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 TEI-XML for    default:Reihe_C/49/ZNC-1994-49c-0312.pdf 
 Identifier    ZNC-1994-49c-0312 
 Volume    49 
15Author    Brigitte Simona, Timm Anke3, U. Andersb, M. Neuhausb, F. HansskebRequires cookie*
 Title    Collybial, a New Antibiotic Sesquiterpenoid from Collybia confluens (Basidiomycetes)  
 Abstract    A new antibiotic was isolated from fermentations of an american strain of Collybia con­ fluens. Its structure was elucidated by spectroscopic methods as 2,10,10-trim ethal-4-oxo-tri-cyclo[7.2.0.025]undec-6-en-carbaldehyde (with the relative stereo chemistry IS, 2 R. 5 R. 9 R) (1). The inhibitor, which was named collybial, is structurally related to koraiol, a sesquiter­ penoid isolated from Pinus koraiensis (Khan V. A . (1979), Khim. Prir. Soedin 5, 6 5 2 -6 5 8). Collybial inhibited the growth of Gram-positive bacteria at concentrations starting from 21.5 | i m . The propagation of vesicular stomatitis virus (V SV) in baby hamster kidney (B H K -21) cells was inhibited by 21.5 [.i m collybial. Cytotoxic effects on B H K cells were observed at 5 fold higher concentrations. 
  Reference    Z. Naturforsch. 50c, 173 (1995); received O ctober 12/Novem ber 11 1994 
  Published    1995 
  Keywords    Collybia confluens, Basidiomycetes, Antibiotic, Antiviral, Cytotoxic Activity 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0173.pdf 
 Identifier    ZNC-1995-50c-0173 
 Volume    50 
16Author    Manfred Schnarr, MichaelM. Atthies, Wolfgang LohmannRequires cookie*
 Title    The Influence of Different Solvents on the Interaction between Metal Ions and Tetracycline  
 Abstract    The interaction o f the antibiotic tetracycline with a few metal ions, esp. Cu(II), in different so l­ vents has been investigated by means o f IR, ESR, and U V /V IS spectroscopy. It could be shown that the site o f com plexation depends on the solvent used. In DM SO the interaction occurs mainly via the A ring. In water (pH = 5.7) and octanol, the A chrom ophore as well as the BCD entity o f the m olecule are involved in com plexation. If the tetracycline concentration exceeds the Cu(II) concentration, a 2 : 1 (antibiotic : Cu(II)) com plex seems to be formed, at least in DM SO. 
  Reference    Z. Naturforsch. 34c, 1156 (1979); received June 25 1979 
  Published    1979 
  Keywords    Tetracycline, Antibiotics, Metal Ions, Com plexation, O ptical Absorption 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-1156.pdf 
 Identifier    ZNC-1979-34c-1156 
 Volume    34 
17Author    H. Eidrun, A. Nke, E. Lisabeth, H. Illen, -. M. Aske, W. Olfgang SteglichRequires cookie*
 Title    9 ß-Hydroxymarasmic Acid and Other Sesquiterpenoids from Submerged Cultures of a Basidiomycete [1]  
 Abstract    9 ß-Hydroxymarasmic acid, a new sesquiterpenoid, marasmic acid and isovelleral were isolated from cultures of a basidiomycete. Comparison of the antimicrobial activity of the three natural compounds together with two n-butyl ether derivatives of marasmic acid revealed MICs against bacteria in the range of 0 .2 —20 ng/ml. The antifungal, cytotoxic and phytotoxic activities of isovelleral were similar to those exhibited by marasmic acid, whereas the marasmic acid deriva­ tives were considerably less active than the parent compound. Isovelleral was the only compound to show hemolytic activity. 
  Reference    Z. Naturforsch. 44c, 1 (1989); received August 31 1988 
  Published    1989 
  Keywords    Marasmic Acid, 9 ß-Hydroxymarasmic Acid, Isovelleral, Sesquiterpenoids, Antibiotics, Basidiomycetes 
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 TEI-XML for    default:Reihe_C/44/ZNC-1989-44c-0001.pdf 
 Identifier    ZNC-1989-44c-0001 
 Volume    44 
18Author    Kirsten Lorenzena, TimmA. Nkea, Silvia Konetschny-Rappb, Werner ScheuerbRequires cookie*
 Title    5-Hydroxy-3-vinyl-2(5H)-furanone -a New Inhibitor of Human Synovial Phospholipase A 2 and Platelet Aggregation from Fermentations of a C alyptella Species (Basidiomycetes)  
 Abstract    5-Hydroxy-3-vinyl-2(5H)-furanone, a potent and selective inhibitor of human synovial phospholipase A 2 was isolated from fermentations of a Calyptella species. Its structure as identified by spectroscopic methods is identical to PA 147, an antibiotic previously isolated from a streptomycete. 5-hydroxy-3-vinyl-2(5H)-furanone inhibits the aggregation of human and bovine platelets stimulated by different inducers and exhibits weak antimicrobial activities. 
  Reference    Z. Naturforsch. 50c, 403—409 (1995); received January 16/February 10 1995 
  Published    1995 
  Keywords    Basidiomycetes, Calyptella Species, Platelet Aggregation, Antibiotics, Phospholipase A 2 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0403.pdf 
 Identifier    ZNC-1995-50c-0403 
 Volume    50