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1997 (1)
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1Author    H.E JRequires cookie*
 Title    Synthetic Studies towards Vinblastine and its Analogues, VI The Markownikov Addition of Acetic Acid to Catharanthine by a Modification of the Prevost Reaction ATTA-UR-RAHMAN, NIGHAT WAHEED, and MARYAM GHAZALA  
 Abstract    The reaction of catharanthine under modified prevost reaction conditions has afforded 20-acetoxydihydrocatharanthine, an important intermediate for the synthesis of anti-leukaemic alkaloids, vinblastine and vincristine. 
  Reference    (Z. Naturforsch. 31b, 264—266 [1976]; received September 4 1975) 
  Published    1976 
  Keywords    Vinblastine, Anti-cancer Drugs, Indole Alkaloids, Prevost Reaction 
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 TEI-XML for    default:Reihe_B/31/ZNB-1976-31b-0264.pdf 
 Identifier    ZNB-1976-31b-0264 
 Volume    31 
2Author    Atta-Ur-Rahman, Sadiqa Firdous, Anwer BashaRequires cookie*
 Title    Alkaloids, IX* Some Aspects of the Chemistry of C atliar anthine  
 Abstract    Vinblastine and Vincristine are binary indole-indoline alkaloids occurring in traces in the leaves of Vinca rosea. They are among the most powerful chemotherapeutic agents available to man for the treatment of a variety of cancers. Their high cost and complexity of structure has attracted the attention of many eminent chemists towards their synthesis. The first synthesis of both these anta'-tumour alkaloids was reported by us last year [7] starting from two major alkaloids, catharanthine and vindo-line, which co-occur in the same plant. Some aspects of the chemistry of catharanthine are now presented including a novel one-step de-carbomethoxylation reaction with H2S in glacial acetic acid and a reversible isomerization of catharanthine with sodium borohydride. A study of the life-time of catharanthine in hot glacial acetic acid substantiates the earlier work of the Anglo-French group on the biosynthesis of indole alkaloids. 
  Reference    Z. Naturforsch. 33b, 469—470 (1978); received December 5 1977 
  Published    1978 
  Keywords    Vinblastine, Vincristine, Decarbomethoxylation, anti-Cancer Drugs, Indole Alkaloids 
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 TEI-XML for    default:Reihe_B/33/ZNB-1978-33b-0469_n.pdf 
 Identifier    ZNB-1978-33b-0469_n 
 Volume    33 
3Author    J. C. Stockert, M. Cañete, A. Villanueva, A. Juarranz, C. I. Trigoso, M. F. BrañaRequires cookie*
 Title    Fluorescence of Chromatin D N A Induced by Antitumoral Naphthalimides  
 Abstract    Treatment of chicken blood smears and semithin sec­ tions from Epon-embedded mouse tissues with aqueous solutions of the 3-aminonaphthalimides FA-142, FA-2043, and FA-2143 induced a strong green-yellow fluo­ rescence of chromatin under violet or violet-blue excita­ tion. Chromatin emission was abolished by previous DNase or hot TCA treatm ent. The use of 3-methoxy (FA-655) and 3-nitro derivatives (M-4212 and M-12210) resulted in very weak fluorescence of chromatin. A b­ sorption maxima at 346 and 408 nm and an emission peak at 570 nm were observed for the free compound FA-142. Fluorescence properties open new and interest­ ing applications for some of these antitum oral and DNA-intercalating naphthalimides. 
  Reference    Z. Naturforsch. 52c, 408—411 (1997); received December 23 1996/February 12 1997 
  Published    1997 
  Keywords    Naphthalimides, Anti-Cancer Drugs, Fluorescence Microscopy DNA Fluorochromes, Chromatin DNA 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0408_n.pdf 
 Identifier    ZNC-1997-52c-0408_n 
 Volume    52