| 1 | Author | HermannL. Lotter | Requires cookie* |
| Title | Untersuchung der Struktur-Wirkungsbeziehung antihepatotoxischer Naturstoffe (Silybin-Antamanid) durch Röntgenstrukturanalyse  | ||
| Abstract | Both, the flavonolignane silybin and the decapeptide antam anide, protect anim als against the mushroom poison phalloidin from Amanita species. The X-ray structures o f silybin and anta manide have been solved in previous studies. Here an attempt has been m ade to explain the antagonistic antihepatotoxic protection by sim ilar chem ical structure elem ents in the two compounds. It can be shown that two aromatic rings in a definite arrangement are essential for the attachment to the target structure o f the liver cell membrane. Com parable pharm acological tests are discussed. | ||
| Reference | Z. Naturforsch. 39c, 535 (1984); received Decem ber 2 1983/March 26 1984 | ||
| Published | 1984 | ||
| Keywords | Silybin, Antamanide, Phalloidin, Structure Activity Relationship, A ntihepatotoxic Principle | ||
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