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'Amino acids' in keywords Facet   section ZfN Section C:Volume 050  [X]
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1995 (1)
1Author    Ricardo FerreiraRequires cookie*
 Title    Why 43 Codons?  
 Abstract    An attempt is made to answer the question posed by the title of this paper. First we show that in primitive self-replicating oligoribotide systems, selection depended from the very start on the existence of 4 kinds of ribotides, forming 2 complementary pairs. Further selection required that the condensation reactions involving the two last positions o f the 3'-end of a growing oligoribotide fragment and the first position of the 5 '-end of another fragment were catalyzed by randomly synthesized peptides. This established a codon -amino acid concen­ tration correlation and clinched triplet segments as the basis o f the translation process. Finally, physical arguments are given to show that the monochirality of the ribotides arose from stereochemical reasons, as firstly described by Wald, but that of the amino acids is the result of natural selection acting during the peptide-assisted stage o f oligoribotide growth. 
  Reference    Z. Naturforsch. 50c, 148 (1995); received August 8 1994 
  Published    1995 
  Keywords    G enetic Code, Codons, Oligoribotides, Amino Acids, Monochirality 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0148.pdf 
 Identifier    ZNC-1995-50c-0148 
 Volume    50