| | 1 | Author
| Abdussalam Maihub, HuiBi Xu, GerhardN. Schrauzer | Requires cookie* | | | Title
| Studies on Vitamin B12 and Related Compounds, 51 [1] Direct Syntheses of Alkylcobalamins from Alkanes and Vitamin B12r under "Oxidizing-Reducing" Conditions  | | | | Abstract
| Syntheses of methylcobalamin from methane, and of n-alkylcobalamins from n-alkanes (C2 C10) and vitamin Bi2r are described. The compounds are formed under "oxidizing-reducing" conditions: Oxygen radicals (02~, HOO -, and HO') are generated from the reaction of O2 with reducing metal ions, notably V +3 (aq) and abstract hydrogen from the alkane substrates. The resulting alkyl radicals are captured by vitamin Bj2r with high efficiency to yield alkylcobalamins. The reactions take place at room temperature in mildly alkaline or acidic solutions. In addition to n-alkylcobalamins, the preparation of neopentylcobalamin from neopentane, of isobutylcobalamin from isobutane, and of several cycloalkylcobalamins from cycloalkanes, is also reported. Methyl radicals generated in D20 from CH4 under "oxidizing-reducing" conditions are reduced to yield CH3D. | | | |
Reference
| Z. Naturforsch. 35b, 1435—1438 (1980); received April 25 1980 | | | |
Published
| 1980 | | | |
Keywords
| Alkylcobalamins, Synthesis, Alkanes | | | |
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| default:Reihe_B/35/ZNB-1980-35b-1435.pdf | | | | Identifier
| ZNB-1980-35b-1435 | | | | Volume
| 35 | |
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